The depletion of MARVELD1 leads to murine placenta accreta via integrin β4‐dependent trophoblast cell invasion
The placenta is a remarkable organ, it serves as the interface between the mother and the fetus. Proper invasion of trophoblast cells is required for a successful pregnancy. Previous studies have found that the adhesion molecule integrin β4 plays important roles during trophoblast cell invasion. Her...
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| Veröffentlicht in: | Journal of cellular physiology 2018-03, Vol.233 (3), p.2257-2269 |
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| creator | Chen, Yue Zhang, Hui Han, Fang Yue, Lei Qiao, Chunxiao Zhang, Yao Dou, Peng Liu, Weizhe Li, Yu |
| description | The placenta is a remarkable organ, it serves as the interface between the mother and the fetus. Proper invasion of trophoblast cells is required for a successful pregnancy. Previous studies have found that the adhesion molecule integrin β4 plays important roles during trophoblast cell invasion. Here, we found that the overall birth rate of the MARVELD1 knockout mouse is much lower than that of the wild‐type mouse (p |
| doi_str_mv | 10.1002/jcp.26098 |
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MARVELD1 (MARVEL domain‐containing 1) is a novel nuclear factor, which is widely expressed in mouse normal tissues, is essential for proper trophoblast cell invasion and successful pregnancy. When MARVELD1 is knocked out, the expression level of integrin β4 is downregulated and the adhesive ability of cells is suppressed, which boost cell migration and invasion, leading to trophoblast cell over‐invasion and the placenta accreta phenotype in MARVELD1 knockout mice.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.26098</identifier><identifier>PMID: 28708243</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Cell Adhesion ; cell invasion ; Cell Line, Tumor ; Cell Movement ; Disease Models, Animal ; Female ; Gene Expression Regulation ; Genetic Predisposition to Disease ; Humans ; Integrin beta4 - genetics ; Integrin beta4 - metabolism ; integrin β4 ; MARVELD1 ; Membrane Proteins - deficiency ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microtubule-Associated Proteins - deficiency ; Microtubule-Associated Proteins - genetics ; Microtubule-Associated Proteins - metabolism ; NIH 3T3 Cells ; Phenotype ; Placenta Accreta - genetics ; Placenta Accreta - metabolism ; Placenta Accreta - pathology ; placenta accrete ; Pregnancy ; Promoter Regions, Genetic ; Signal Transduction ; trophoblast cell ; Trophoblasts - metabolism ; Trophoblasts - pathology</subject><ispartof>Journal of cellular physiology, 2018-03, Vol.233 (3), p.2257-2269</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2758-3813f2f71ebedf6230098594b0f466ef461adb111a521ac1d67c47884793866c3</citedby><cites>FETCH-LOGICAL-c2758-3813f2f71ebedf6230098594b0f466ef461adb111a521ac1d67c47884793866c3</cites><orcidid>0000-0003-3484-946X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.26098$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.26098$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28708243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Yue</creatorcontrib><creatorcontrib>Zhang, Hui</creatorcontrib><creatorcontrib>Han, Fang</creatorcontrib><creatorcontrib>Yue, Lei</creatorcontrib><creatorcontrib>Qiao, Chunxiao</creatorcontrib><creatorcontrib>Zhang, Yao</creatorcontrib><creatorcontrib>Dou, Peng</creatorcontrib><creatorcontrib>Liu, Weizhe</creatorcontrib><creatorcontrib>Li, Yu</creatorcontrib><title>The depletion of MARVELD1 leads to murine placenta accreta via integrin β4‐dependent trophoblast cell invasion</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>The placenta is a remarkable organ, it serves as the interface between the mother and the fetus. Proper invasion of trophoblast cells is required for a successful pregnancy. Previous studies have found that the adhesion molecule integrin β4 plays important roles during trophoblast cell invasion. Here, we found that the overall birth rate of the MARVELD1 knockout mouse is much lower than that of the wild‐type mouse (p < 0.001). In E18.5 MARVELD1 knockout mice, we observed an over‐invasion of trophoblast cells, and indeed, the pregnant mice had a partial placenta accreta phenotype. The HTR8/SVneo cell line was used as an in vitro model to elucidate the underlying mechanisms of MARVELD1‐mediated trophoblast invasion. We detected a diminished expression of integrin β4 upon the downregulation of MARVELD1 and enhanced migrate and invasive abilities of trophoblast cells both in vivo and in vitro. The integrin β4 rescue assay also supported the results. In conclusion, this study found that MARVELD1 mediated the invasion of trophoblast cells via regulating the expression of integrin β4 during placenta development.
MARVELD1 (MARVEL domain‐containing 1) is a novel nuclear factor, which is widely expressed in mouse normal tissues, is essential for proper trophoblast cell invasion and successful pregnancy. When MARVELD1 is knocked out, the expression level of integrin β4 is downregulated and the adhesive ability of cells is suppressed, which boost cell migration and invasion, leading to trophoblast cell over‐invasion and the placenta accreta phenotype in MARVELD1 knockout mice.</description><subject>Animals</subject><subject>Cell Adhesion</subject><subject>cell invasion</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Gene Expression Regulation</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Integrin beta4 - genetics</subject><subject>Integrin beta4 - metabolism</subject><subject>integrin β4</subject><subject>MARVELD1</subject><subject>Membrane Proteins - deficiency</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Microtubule-Associated Proteins - deficiency</subject><subject>Microtubule-Associated Proteins - genetics</subject><subject>Microtubule-Associated Proteins - metabolism</subject><subject>NIH 3T3 Cells</subject><subject>Phenotype</subject><subject>Placenta Accreta - genetics</subject><subject>Placenta Accreta - metabolism</subject><subject>Placenta Accreta - pathology</subject><subject>placenta accrete</subject><subject>Pregnancy</subject><subject>Promoter Regions, Genetic</subject><subject>Signal Transduction</subject><subject>trophoblast cell</subject><subject>Trophoblasts - metabolism</subject><subject>Trophoblasts - pathology</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtOwzAQhi0EoqWw4ALIS1ik9Tgve1mV8lIRCBW2keNMaKo0CXFS1B1H4CwchENwElxa2LGZfzGfvhn9hBwD6wNjfDDXVZ8HTIod0gUmQ8cLfL5LunYHjvQ96JADY-aMMSldd590uAiZ4J7bJS_TGdIEqxybrCxomdLb4cPTeHIONEeVGNqUdNHWWYG0ypXGolFUaV2jzWWmaFY0-GzX9PPD-3p7tyYsEkvRpi6rWRnnyjRUY55bcqmMvXFI9lKVGzzaZo88Xoynoytncnd5PRpOHM1DXziuADflaQgYY5IG3LXPC196MUu9IEA7QCUxACifg9KQBKH2QiG8ULoiCLTbI6cbb1WXLy2aJlpkZv2JKrBsTQSSM5CChb5Fzzaorktjakyjqs4Wql5FwKJ1w5FtOPpp2LInW20bLzD5I38rtcBgA7xmOa7-N0U3o_uN8hsUMIZg</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>Chen, Yue</creator><creator>Zhang, Hui</creator><creator>Han, Fang</creator><creator>Yue, Lei</creator><creator>Qiao, Chunxiao</creator><creator>Zhang, Yao</creator><creator>Dou, Peng</creator><creator>Liu, Weizhe</creator><creator>Li, Yu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3484-946X</orcidid></search><sort><creationdate>201803</creationdate><title>The depletion of MARVELD1 leads to murine placenta accreta via integrin β4‐dependent trophoblast cell invasion</title><author>Chen, Yue ; Zhang, Hui ; Han, Fang ; Yue, Lei ; Qiao, Chunxiao ; Zhang, Yao ; Dou, Peng ; Liu, Weizhe ; Li, Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2758-3813f2f71ebedf6230098594b0f466ef461adb111a521ac1d67c47884793866c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Cell Adhesion</topic><topic>cell invasion</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Gene Expression Regulation</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Integrin beta4 - genetics</topic><topic>Integrin beta4 - metabolism</topic><topic>integrin β4</topic><topic>MARVELD1</topic><topic>Membrane Proteins - deficiency</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Microtubule-Associated Proteins - deficiency</topic><topic>Microtubule-Associated Proteins - genetics</topic><topic>Microtubule-Associated Proteins - metabolism</topic><topic>NIH 3T3 Cells</topic><topic>Phenotype</topic><topic>Placenta Accreta - genetics</topic><topic>Placenta Accreta - metabolism</topic><topic>Placenta Accreta - pathology</topic><topic>placenta accrete</topic><topic>Pregnancy</topic><topic>Promoter Regions, Genetic</topic><topic>Signal Transduction</topic><topic>trophoblast cell</topic><topic>Trophoblasts - metabolism</topic><topic>Trophoblasts - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yue</creatorcontrib><creatorcontrib>Zhang, Hui</creatorcontrib><creatorcontrib>Han, Fang</creatorcontrib><creatorcontrib>Yue, Lei</creatorcontrib><creatorcontrib>Qiao, Chunxiao</creatorcontrib><creatorcontrib>Zhang, Yao</creatorcontrib><creatorcontrib>Dou, Peng</creatorcontrib><creatorcontrib>Liu, Weizhe</creatorcontrib><creatorcontrib>Li, Yu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Yue</au><au>Zhang, Hui</au><au>Han, Fang</au><au>Yue, Lei</au><au>Qiao, Chunxiao</au><au>Zhang, Yao</au><au>Dou, Peng</au><au>Liu, Weizhe</au><au>Li, Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The depletion of MARVELD1 leads to murine placenta accreta via integrin β4‐dependent trophoblast cell invasion</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2018-03</date><risdate>2018</risdate><volume>233</volume><issue>3</issue><spage>2257</spage><epage>2269</epage><pages>2257-2269</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>The placenta is a remarkable organ, it serves as the interface between the mother and the fetus. Proper invasion of trophoblast cells is required for a successful pregnancy. Previous studies have found that the adhesion molecule integrin β4 plays important roles during trophoblast cell invasion. Here, we found that the overall birth rate of the MARVELD1 knockout mouse is much lower than that of the wild‐type mouse (p < 0.001). In E18.5 MARVELD1 knockout mice, we observed an over‐invasion of trophoblast cells, and indeed, the pregnant mice had a partial placenta accreta phenotype. The HTR8/SVneo cell line was used as an in vitro model to elucidate the underlying mechanisms of MARVELD1‐mediated trophoblast invasion. We detected a diminished expression of integrin β4 upon the downregulation of MARVELD1 and enhanced migrate and invasive abilities of trophoblast cells both in vivo and in vitro. The integrin β4 rescue assay also supported the results. In conclusion, this study found that MARVELD1 mediated the invasion of trophoblast cells via regulating the expression of integrin β4 during placenta development.
MARVELD1 (MARVEL domain‐containing 1) is a novel nuclear factor, which is widely expressed in mouse normal tissues, is essential for proper trophoblast cell invasion and successful pregnancy. When MARVELD1 is knocked out, the expression level of integrin β4 is downregulated and the adhesive ability of cells is suppressed, which boost cell migration and invasion, leading to trophoblast cell over‐invasion and the placenta accreta phenotype in MARVELD1 knockout mice.</abstract><cop>United States</cop><pmid>28708243</pmid><doi>10.1002/jcp.26098</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-3484-946X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Cell Adhesion cell invasion Cell Line, Tumor Cell Movement Disease Models, Animal Female Gene Expression Regulation Genetic Predisposition to Disease Humans Integrin beta4 - genetics Integrin beta4 - metabolism integrin β4 MARVELD1 Membrane Proteins - deficiency Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Microtubule-Associated Proteins - deficiency Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism NIH 3T3 Cells Phenotype Placenta Accreta - genetics Placenta Accreta - metabolism Placenta Accreta - pathology placenta accrete Pregnancy Promoter Regions, Genetic Signal Transduction trophoblast cell Trophoblasts - metabolism Trophoblasts - pathology |
| title | The depletion of MARVELD1 leads to murine placenta accreta via integrin β4‐dependent trophoblast cell invasion |
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