The depletion of MARVELD1 leads to murine placenta accreta via integrin β4‐dependent trophoblast cell invasion

The placenta is a remarkable organ, it serves as the interface between the mother and the fetus. Proper invasion of trophoblast cells is required for a successful pregnancy. Previous studies have found that the adhesion molecule integrin β4 plays important roles during trophoblast cell invasion. Her...

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Veröffentlicht in:	Journal of cellular physiology 2018-03, Vol.233 (3), p.2257-2269
Hauptverfasser:	Chen, Yue, Zhang, Hui, Han, Fang, Yue, Lei, Qiao, Chunxiao, Zhang, Yao, Dou, Peng, Liu, Weizhe, Li, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Adhesion cell invasion Cell Line, Tumor Cell Movement Disease Models, Animal Female Gene Expression Regulation Genetic Predisposition to Disease Humans Integrin beta4 - genetics Integrin beta4 - metabolism integrin β4 MARVELD1 Membrane Proteins - deficiency Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Microtubule-Associated Proteins - deficiency Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism NIH 3T3 Cells Phenotype Placenta Accreta - genetics Placenta Accreta - metabolism Placenta Accreta - pathology placenta accrete Pregnancy Promoter Regions, Genetic Signal Transduction trophoblast cell Trophoblasts - metabolism Trophoblasts - pathology
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Zusammenfassung:	The placenta is a remarkable organ, it serves as the interface between the mother and the fetus. Proper invasion of trophoblast cells is required for a successful pregnancy. Previous studies have found that the adhesion molecule integrin β4 plays important roles during trophoblast cell invasion. Here, we found that the overall birth rate of the MARVELD1 knockout mouse is much lower than that of the wild‐type mouse (p
ISSN:	0021-9541 1097-4652
DOI:	10.1002/jcp.26098