Elevated homocysteine in human abdominal aortic aneurysmal tissues

An abnormally high level of homocysteine (Hcy) has been consistently observed in the blood of abdominal aortic aneurysm (AAA) patients. However, the expression of Hcy in human AAA tissues has not been investigated. In this study, the expression of Hcy in aneurysmal tissues from AAA patients (n=30) w...

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Veröffentlicht in:	Vascular medicine (London, England) England), 2017-10, Vol.22 (5), p.370-377
Hauptverfasser:	Chan, Crystal Yin Tung, Cheng, Stephen Wing Keung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Aneurysms Aorta, Abdominal - metabolism Aortic Aneurysm, Abdominal - enzymology Aortic Aneurysm, Abdominal - genetics Aortic Aneurysm, Abdominal - metabolism Aortic aneurysms Case-Control Studies Cell culture Cells, Cultured Culture Media, Conditioned - metabolism Female Homocysteine Homocysteine - metabolism Humans Immunohistochemistry Male Methylenetetrahydrofolate reductase Methylenetetrahydrofolate Reductase (NADPH2) - genetics Middle Aged Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - metabolism Organ donors Patients Polymerase chain reaction Polymorphism Polymorphism, Genetic Restriction fragment length polymorphism Smooth muscle Tissue Culture Techniques Tissues Up-Regulation
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Zusammenfassung:	An abnormally high level of homocysteine (Hcy) has been consistently observed in the blood of abdominal aortic aneurysm (AAA) patients. However, the expression of Hcy in human AAA tissues has not been investigated. In this study, the expression of Hcy in aneurysmal tissues from AAA patients (n=30) was compared with non-aneurysmal tissues from organ donors (n=31) by dot blotting and immunohistochemistry. A significantly higher expression of Hcy was observed in AAA than control tissues (p
ISSN:	1358-863X 1477-0377
DOI:	10.1177/1358863X17718260