A Rapid Synthesis of Pyranoid Glycals Promoted by β-Cyclodextrin and Ultrasound
A convenient and environmentally benign procedure for the synthesis of glycals from glycosyl bromides with very low zinc dust loading （1.5 equiv.） is described. The process is activated by β-cyclodextrin and ultrasound. Based on 19 samples, this method has been demonstrated to be highly effective fo...
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| Veröffentlicht in: | Chinese journal of chemistry 2011-07, Vol.29 (7), p.1434-1440 |
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| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | A convenient and environmentally benign procedure for the synthesis of glycals from glycosyl bromides with very low zinc dust loading （1.5 equiv.） is described. The process is activated by β-cyclodextrin and ultrasound. Based on 19 samples, this method has been demonstrated to be highly effective for a broad range of glycosyl bromides, including acidor base-sensitive and disaccharide glycosyl bromides. A yield of 85%--96% of glycals was obtained. |
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| ISSN: | 1001-604X 1614-7065 |
| DOI: | 10.1002/cjoc.201180263 |