Effect of heme oxygenase‐1 gene promoter polymorphism on cancer risk by histological subtype: A prospective study in arseniasis‐endemic areas in Taiwan

Heme oxygenase (HO)−1 is upregulated by many stressful stimuli, including arsenic. A GT‐repeat ((GT)n) polymorphism in the HO‐1 gene promoter inversely modulates the levels of HO‐1 induction. Previous HO‐1 (GT)n polymorphism studies in relation to cancer risk have shown disparate results. We prospec...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of cancer 2016-04, Vol.138 (8), p.1875-1886
Hauptverfasser:	Wu, Meei‐Maan, Lee, Chih‐Hung, Hsu, Ling‐I, Cheng, Wen‐Fang, Lee, Te‐Chang, Wang, Yuang‐Hung, Chiou, Hung‐Yi, Chen, Chien‐Jen
Format:	Artikel
Sprache:	eng
Schlagworte:	Arsenic arsenic exposure Arsenic Poisoning - complications Arsenic Poisoning - epidemiology Arsenic Poisoning - genetics Bowen's disease Cancer cancer risk Drinking Water - adverse effects Endemic Diseases Female Fluorescent Antibody Technique genetic polymorphism Genetic Predisposition to Disease - genetics Genotype Genotype & phenotype Heme Oxygenase-1 - genetics heme oxygenase‐1 Histology Humans Incidence Lung cancer Male Medical research Middle Aged Neoplasms - chemically induced Neoplasms - enzymology Neoplasms - genetics Polymorphism Polymorphism, Single Nucleotide Promoter Regions, Genetic - genetics Proportional Hazards Models Prospective Studies Reverse Transcriptase Polymerase Chain Reaction Risk factors Taiwan - epidemiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Heme oxygenase (HO)−1 is upregulated by many stressful stimuli, including arsenic. A GT‐repeat ((GT)n) polymorphism in the HO‐1 gene promoter inversely modulates the levels of HO‐1 induction. Previous HO‐1 (GT)n polymorphism studies in relation to cancer risk have shown disparate results. We prospectively investigated the associations between HO‐1 (GT)n polymorphism and cancer risk related to arsenic from drinking water. Totally, 1,013 participants from community‐based cohorts of arseniasis‐endemic areas in Taiwan were followed for 13 years. Allelic polymorphisms were classified into long (L, ≥27 (GT)n) and short (S,
ISSN:	0020-7136 1097-0215
DOI:	10.1002/ijc.29926