Synthesis and Antimicrobial Activity of 2-Methyl-5-nitroaniline Derivatives: A Structure-Activity Relationship Study

A series of 2-methyl-5-nitroaniline derivatives, 5a--Sk and 6a--6f, were synthesized in order to determine their in vitro antimicrobial activity. The chemical structures of the synthesized compounds were confirmed by elemental analyses, UV-visible, FT-IR, 1H NMR and 13C NMR spectral studies. The str...

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Veröffentlicht in:Chinese journal of chemistry 2011, Vol.29 (1), p.102-108
1. Verfasser: Lingappa, Mallesha Kikkeri, N. Mohana Devaraju, Rakshith Sreedharamurthy, Satish
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Sprache:eng
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Zusammenfassung:A series of 2-methyl-5-nitroaniline derivatives, 5a--Sk and 6a--6f, were synthesized in order to determine their in vitro antimicrobial activity. The chemical structures of the synthesized compounds were confirmed by elemental analyses, UV-visible, FT-IR, 1H NMR and 13C NMR spectral studies. The structure-activity relationships of the synthesized compounds were also discussed. Among the synthesized compounds, 5f, 5d, 6b and 6e showed good antimicrobial activity compared to standard drugs.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201190034