Knee flexion contracture treated with botulinum toxin type A in patients with haemophilia (PWH)

Introduction Knee flexion contracture (KFC) remains a common complication of haemoarthrosis in children and young adults with haemophilia. If the KFC is not treated properly it produces disability, postural and gait abnormalities. Objective Evaluate the effectiveness of conservative treatment of KFC with Botulinum toxin type A (BTX‐A) in PWH. Methods Seventeen patients were treated, with 21 affected knees. Mean age was 26 years. The mean follow up was 12 months. We evaluated flexion and KFC pretreatment BTX‐A and up to 12 months posttreatment. BTX‐A application was in hamstring and calf muscles. To evaluate the function, a questionnaire about different activities was made, and it was checked 3, 6 and 12 months after BTX‐A. According to the degree of KFC, knees were divided into 3 groups: Group 1: −10° to −30° (n = 10), Group 2: −31° to −45° (n = 6) Group 3: −46° or more (n = 5). Results The average KFC improved from −38° to −24°. The improvement was 14° (P