Ruthenium-catalyzed site-selective C-H arylation of 2-pyridones and 1-isoquinolinones

An efficient Ru(ii)-catalyzed site-selective C-H arylation of 2-pyridones and 1-isoquinolinones was achieved with boronic acids by using pyridine as a directing group. The developed protocol is general and provides rapid access to an array of C6-arylated 2-pyridones and C3-arylated 1-isoquinolinones...

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Veröffentlicht in:Organic & biomolecular chemistry 2017, Vol.15 (26), p.5457-5461
Hauptverfasser: Anil Kumar, K, Kannaboina, Prakash, Das, Parthasarathi
Format: Artikel
Sprache:eng
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Zusammenfassung:An efficient Ru(ii)-catalyzed site-selective C-H arylation of 2-pyridones and 1-isoquinolinones was achieved with boronic acids by using pyridine as a directing group. The developed protocol is general and provides rapid access to an array of C6-arylated 2-pyridones and C3-arylated 1-isoquinolinones in excellent yields. These designed arylated 2-pyridones and 1-isoquinolinones can serve as key structural motifs for accessing functionalized pyridines and isoquinolines.
ISSN:1477-0520
1477-0539
DOI:10.1039/c7ob01277b