β-Glucan inhibits the genotoxicity of cyclophosphamide, adriamycin and cisplatin

The inhibitory effects of β-glucan (βG), one of the biological response modifiers, on the induction of chromosomal aberrations in the bone marrow and spermatogonial cells of mice treated with various anti-neoplastic drugs were investigated. β-Glucan (100 mg/kg bw, i.p.) pre-treatment reduced the tot...

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Veröffentlicht in:	Mutation research 2003-11, Vol.541 (1), p.45-53
Hauptverfasser:	Tohamy, Amany A, El-Ghor, Akmal A, El-Nahas, Soheir M, Noshy, Magda M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adriamycin Animals Antineoplastic Agents - toxicity Biological and medical sciences Bone Marrow Cells - drug effects Chromosome Aberrations Cisplatin Cisplatin - toxicity Cyclophosphamide Cyclophosphamide - toxicity Doxorubicin - toxicity Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Genotoxicity Glucans - pharmacology Hydroxyl Radical Male Medical sciences Mice Mitosis - drug effects Spermatogonia - drug effects Toxicology β-Glucan
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