β-Glucan inhibits the genotoxicity of cyclophosphamide, adriamycin and cisplatin

The inhibitory effects of β-glucan (βG), one of the biological response modifiers, on the induction of chromosomal aberrations in the bone marrow and spermatogonial cells of mice treated with various anti-neoplastic drugs were investigated. β-Glucan (100 mg/kg bw, i.p.) pre-treatment reduced the tot...

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Veröffentlicht in:Mutation research 2003-11, Vol.541 (1), p.45-53
Hauptverfasser: Tohamy, Amany A, El-Ghor, Akmal A, El-Nahas, Soheir M, Noshy, Magda M
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Sprache:eng
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Zusammenfassung:The inhibitory effects of β-glucan (βG), one of the biological response modifiers, on the induction of chromosomal aberrations in the bone marrow and spermatogonial cells of mice treated with various anti-neoplastic drugs were investigated. β-Glucan (100 mg/kg bw, i.p.) pre-treatment reduced the total number of cells with structural chromosomal aberrations scored after the treatment with cyclophosphamide (CP) (2.5 mg/kg bw, i.p.) adriamycin (ADR) (12 mg/kg bw, i.p.) and cis-diamminedichloroplatinum-II (cisplatin) (5 mg/kg bw, i.p.) by about 41.1, 26.9 and 57.7% in bone marrow and 44.4, 55 and 57.1% in spermatogonial cells, respectively. This protective effect of β-glucan could be attributed to its scavenging ability to trap free-radicals produced during the biotransformation of these anti-neoplastic drugs. β-Glucan also markedly restored the mitotic activity of bone marrow cells that had been suppressed by the anti-neoplastic drugs. These results indicate that in addition to the known immunopotentiating activity of β-glucan, it plays a role in reducing genotoxicity induced by anti-neoplastic drugs during cancer chemotherapy.
ISSN:1383-5718
0027-5107
1879-3592
DOI:10.1016/S1383-5718(03)00184-0