β-Glucan inhibits the genotoxicity of cyclophosphamide, adriamycin and cisplatin
The inhibitory effects of β-glucan (βG), one of the biological response modifiers, on the induction of chromosomal aberrations in the bone marrow and spermatogonial cells of mice treated with various anti-neoplastic drugs were investigated. β-Glucan (100 mg/kg bw, i.p.) pre-treatment reduced the tot...
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| Veröffentlicht in: | Mutation research 2003-11, Vol.541 (1), p.45-53 |
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| creator | Tohamy, Amany A El-Ghor, Akmal A El-Nahas, Soheir M Noshy, Magda M |
| description | The inhibitory effects of β-glucan (βG), one of the biological response modifiers, on the induction of chromosomal aberrations in the bone marrow and spermatogonial cells of mice treated with various anti-neoplastic drugs were investigated. β-Glucan (100
mg/kg bw, i.p.) pre-treatment reduced the total number of cells with structural chromosomal aberrations scored after the treatment with cyclophosphamide (CP) (2.5
mg/kg bw, i.p.) adriamycin (ADR) (12
mg/kg bw, i.p.) and
cis-diamminedichloroplatinum-II (cisplatin) (5
mg/kg bw, i.p.) by about 41.1, 26.9 and 57.7% in bone marrow and 44.4, 55 and 57.1% in spermatogonial cells, respectively. This protective effect of β-glucan could be attributed to its scavenging ability to trap free-radicals produced during the biotransformation of these anti-neoplastic drugs.
β-Glucan also markedly restored the mitotic activity of bone marrow cells that had been suppressed by the anti-neoplastic drugs. These results indicate that in addition to the known immunopotentiating activity of β-glucan, it plays a role in reducing genotoxicity induced by anti-neoplastic drugs during cancer chemotherapy. |
| doi_str_mv | 10.1016/S1383-5718(03)00184-0 |
| format | Article |
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mg/kg bw, i.p.) pre-treatment reduced the total number of cells with structural chromosomal aberrations scored after the treatment with cyclophosphamide (CP) (2.5
mg/kg bw, i.p.) adriamycin (ADR) (12
mg/kg bw, i.p.) and
cis-diamminedichloroplatinum-II (cisplatin) (5
mg/kg bw, i.p.) by about 41.1, 26.9 and 57.7% in bone marrow and 44.4, 55 and 57.1% in spermatogonial cells, respectively. This protective effect of β-glucan could be attributed to its scavenging ability to trap free-radicals produced during the biotransformation of these anti-neoplastic drugs.
β-Glucan also markedly restored the mitotic activity of bone marrow cells that had been suppressed by the anti-neoplastic drugs. These results indicate that in addition to the known immunopotentiating activity of β-glucan, it plays a role in reducing genotoxicity induced by anti-neoplastic drugs during cancer chemotherapy.</description><identifier>ISSN: 1383-5718</identifier><identifier>ISSN: 0027-5107</identifier><identifier>EISSN: 1879-3592</identifier><identifier>DOI: 10.1016/S1383-5718(03)00184-0</identifier><identifier>PMID: 14568293</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adriamycin ; Animals ; Antineoplastic Agents - toxicity ; Biological and medical sciences ; Bone Marrow Cells - drug effects ; Chromosome Aberrations ; Cisplatin ; Cisplatin - toxicity ; Cyclophosphamide ; Cyclophosphamide - toxicity ; Doxorubicin - toxicity ; Fundamental and applied biological sciences. Psychology ; Genetics of eukaryotes. Biological and molecular evolution ; Genotoxicity ; Glucans - pharmacology ; Hydroxyl Radical ; Male ; Medical sciences ; Mice ; Mitosis - drug effects ; Spermatogonia - drug effects ; Toxicology ; β-Glucan</subject><ispartof>Mutation research, 2003-11, Vol.541 (1), p.45-53</ispartof><rights>2003</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-8e6818e75a3f1dbf93f4dd75df7000364b7e6031f1d5bb198728eccea6f071603</citedby><cites>FETCH-LOGICAL-c422t-8e6818e75a3f1dbf93f4dd75df7000364b7e6031f1d5bb198728eccea6f071603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1383-5718(03)00184-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15205585$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14568293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tohamy, Amany A</creatorcontrib><creatorcontrib>El-Ghor, Akmal A</creatorcontrib><creatorcontrib>El-Nahas, Soheir M</creatorcontrib><creatorcontrib>Noshy, Magda M</creatorcontrib><title>β-Glucan inhibits the genotoxicity of cyclophosphamide, adriamycin and cisplatin</title><title>Mutation research</title><addtitle>Mutat Res</addtitle><description>The inhibitory effects of β-glucan (βG), one of the biological response modifiers, on the induction of chromosomal aberrations in the bone marrow and spermatogonial cells of mice treated with various anti-neoplastic drugs were investigated. β-Glucan (100
mg/kg bw, i.p.) pre-treatment reduced the total number of cells with structural chromosomal aberrations scored after the treatment with cyclophosphamide (CP) (2.5
mg/kg bw, i.p.) adriamycin (ADR) (12
mg/kg bw, i.p.) and
cis-diamminedichloroplatinum-II (cisplatin) (5
mg/kg bw, i.p.) by about 41.1, 26.9 and 57.7% in bone marrow and 44.4, 55 and 57.1% in spermatogonial cells, respectively. This protective effect of β-glucan could be attributed to its scavenging ability to trap free-radicals produced during the biotransformation of these anti-neoplastic drugs.
β-Glucan also markedly restored the mitotic activity of bone marrow cells that had been suppressed by the anti-neoplastic drugs. These results indicate that in addition to the known immunopotentiating activity of β-glucan, it plays a role in reducing genotoxicity induced by anti-neoplastic drugs during cancer chemotherapy.</description><subject>Adriamycin</subject><subject>Animals</subject><subject>Antineoplastic Agents - toxicity</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Cells - drug effects</subject><subject>Chromosome Aberrations</subject><subject>Cisplatin</subject><subject>Cisplatin - toxicity</subject><subject>Cyclophosphamide</subject><subject>Cyclophosphamide - toxicity</subject><subject>Doxorubicin - toxicity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genotoxicity</subject><subject>Glucans - pharmacology</subject><subject>Hydroxyl Radical</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mitosis - drug effects</subject><subject>Spermatogonia - drug effects</subject><subject>Toxicology</subject><subject>β-Glucan</subject><issn>1383-5718</issn><issn>0027-5107</issn><issn>1879-3592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkNtu1DAQhi0E6ok-Aig3oFYiMBPHiXNVoaotSJUqBFxbjj1mjRI72FnEvlYfpM9Etruol1zNSP83B32MvUJ4j4DNh6_IJS9Fi_IM-DkAyrqEZ-wIZduVXHTV86X_hxyy45x_AlTAQR6wQ6xFI6uOH7EvD_flzbA2OhQ-rHzv51zMKyp-UIhz_OONnzdFdIXZmCFOq5inlR69pXeFtsnrcWN8KHSwhfF5GvTsw0v2wukh0-m-nrDv11ffLj-Vt3c3ny8_3pamrqq5lNRIlNQKzR3a3nXc1da2wroWAHhT9y01wHEJRd9jJ9tKkjGkGwctLskJe7vbO6X4a015VqPPhoZBB4rrrLDDrkHZLaDYgSbFnBM5NSU_6rRRCGrrUj26VFtRCrh6dKm2B17vD6z7kezT1F7eArzZAzobPbikw2LhiRMVCCHFwl3sOFp0_PaUVDaegiHrE5lZ2ej_88pf7TWRvA</recordid><startdate>20031110</startdate><enddate>20031110</enddate><creator>Tohamy, Amany A</creator><creator>El-Ghor, Akmal A</creator><creator>El-Nahas, Soheir M</creator><creator>Noshy, Magda M</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20031110</creationdate><title>β-Glucan inhibits the genotoxicity of cyclophosphamide, adriamycin and cisplatin</title><author>Tohamy, Amany A ; El-Ghor, Akmal A ; El-Nahas, Soheir M ; Noshy, Magda M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-8e6818e75a3f1dbf93f4dd75df7000364b7e6031f1d5bb198728eccea6f071603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adriamycin</topic><topic>Animals</topic><topic>Antineoplastic Agents - toxicity</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Cells - drug effects</topic><topic>Chromosome Aberrations</topic><topic>Cisplatin</topic><topic>Cisplatin - toxicity</topic><topic>Cyclophosphamide</topic><topic>Cyclophosphamide - toxicity</topic><topic>Doxorubicin - toxicity</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genotoxicity</topic><topic>Glucans - pharmacology</topic><topic>Hydroxyl Radical</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mitosis - drug effects</topic><topic>Spermatogonia - drug effects</topic><topic>Toxicology</topic><topic>β-Glucan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tohamy, Amany A</creatorcontrib><creatorcontrib>El-Ghor, Akmal A</creatorcontrib><creatorcontrib>El-Nahas, Soheir M</creatorcontrib><creatorcontrib>Noshy, Magda M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Mutation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tohamy, Amany A</au><au>El-Ghor, Akmal A</au><au>El-Nahas, Soheir M</au><au>Noshy, Magda M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>β-Glucan inhibits the genotoxicity of cyclophosphamide, adriamycin and cisplatin</atitle><jtitle>Mutation research</jtitle><addtitle>Mutat Res</addtitle><date>2003-11-10</date><risdate>2003</risdate><volume>541</volume><issue>1</issue><spage>45</spage><epage>53</epage><pages>45-53</pages><issn>1383-5718</issn><issn>0027-5107</issn><eissn>1879-3592</eissn><abstract>The inhibitory effects of β-glucan (βG), one of the biological response modifiers, on the induction of chromosomal aberrations in the bone marrow and spermatogonial cells of mice treated with various anti-neoplastic drugs were investigated. β-Glucan (100
mg/kg bw, i.p.) pre-treatment reduced the total number of cells with structural chromosomal aberrations scored after the treatment with cyclophosphamide (CP) (2.5
mg/kg bw, i.p.) adriamycin (ADR) (12
mg/kg bw, i.p.) and
cis-diamminedichloroplatinum-II (cisplatin) (5
mg/kg bw, i.p.) by about 41.1, 26.9 and 57.7% in bone marrow and 44.4, 55 and 57.1% in spermatogonial cells, respectively. This protective effect of β-glucan could be attributed to its scavenging ability to trap free-radicals produced during the biotransformation of these anti-neoplastic drugs.
β-Glucan also markedly restored the mitotic activity of bone marrow cells that had been suppressed by the anti-neoplastic drugs. These results indicate that in addition to the known immunopotentiating activity of β-glucan, it plays a role in reducing genotoxicity induced by anti-neoplastic drugs during cancer chemotherapy.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>14568293</pmid><doi>10.1016/S1383-5718(03)00184-0</doi><tpages>9</tpages></addata></record> |
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| subjects | Adriamycin Animals Antineoplastic Agents - toxicity Biological and medical sciences Bone Marrow Cells - drug effects Chromosome Aberrations Cisplatin Cisplatin - toxicity Cyclophosphamide Cyclophosphamide - toxicity Doxorubicin - toxicity Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Genotoxicity Glucans - pharmacology Hydroxyl Radical Male Medical sciences Mice Mitosis - drug effects Spermatogonia - drug effects Toxicology β-Glucan |
| title | β-Glucan inhibits the genotoxicity of cyclophosphamide, adriamycin and cisplatin |
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