Cobalt-Catalyzed Cross-Couplings of Bench-Stable Alkynylzinc Pivalates with (Hetero)Aryl and Alkenyl Halides

Cobalt-Catalyzed Cross-Couplings of Bench-Stable Alkynylzinc Pivalates with (Hetero)Aryl and Alkenyl Halides

A catalytic system consisting of CoCl2·2LiCl and TMEDA enables the cross-coupling of various electron-poor aryl and heteroaryl halides with various alkynylzinc pivalates. Coupling with alkenyl halides proceeds with retention of configuration.

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Veröffentlicht in:Organic letters 2017-07, Vol.19 (14), p.3847-3850
Hauptverfasser: Hammann, Jeffrey M, Thomas, Lucie, Chen, Yi-Hung, Haas, Diana, Knochel, Paul
Format: Artikel
Sprache:eng
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Zusammenfassung:A catalytic system consisting of CoCl2·2LiCl and TMEDA enables the cross-coupling of various electron-poor aryl and heteroaryl halides with various alkynylzinc pivalates. Coupling with alkenyl halides proceeds with retention of configuration.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b01722