Normal cerebral vascular pulsations in humans: changes with age and implications for microvascular disease

BACKGROUND:Cerebral syndromes in older humans, secondary stroke in younger persons following trauma, and sickle cell anaemia in children, are linked by unexplained microvascular damage and high cerebral pressure or flow pulsations. The aim of this study was to characterize age-related pressure and flow waveforms patterns entering the brain, to explain these in terms of disturbed physiological function, and to consider clinical implications. METHOD:Blood flow velocity waves were measured in four cerebral vascular territories by transcranial Doppler of 1020 apparently normal patients (497 men, 21–78 years). Central pressure waveforms were generated from radial artery applanation tonometry with SphygmoCor. Relationships were described in time and frequency domains. RESULTS AND CONCLUSION:Flow waveforms entering the brain showed similar pattern to central aortic pressure waveforms, and similar changes with age. Augmentation index of flow and of pressure had high correlation at different ages, and in men and women (r = 0.58, P