Current advances and future visions on bioelectronic immunosensing for prostate-specific antigen

Early cancer diagnosis remains the holy-grail in the battle against cancers progression. Tainted with debates and medical challenges, current therapeutic approaches for prostate cancer (PCa) lack early preventive measures, rapid diagnostic capabilities, risk factors identification, and portability, i.e. the inherent attributes offered by the label-free biosensing devices. Electronic assisted immunosensing systems inherit the high sensitivity and specificity properties due to the predilection of the antigen–antibody affinity. Bioelectronic immunosensor for PCa has attracted much attentions among the researchers due to its high-performance, easy to prepare, rapid feedback, and possibility for miniaturization. This review explores the current advances on bioelectronic immunosensors for the detection of PCa biomarker revealed in the past decade. The research milestones and current trends of the immunosensors are reported to project the future visions in order to propel their “lab-to-market” realization. [Display omitted] •A concise review on immunosensor for prostate cancer's detection is presented.•The field-effect transistors and customized-electrodes devices-based sensors offer the highest LODs and portability.•The future visions of prostate-specific antigen (PSA) biosensing are discussed.