Bilirubin coating attenuates the inflammatory response to everolimus-coated stents

Bilirubin coating attenuates the inflammatory response to everolimus-coated stents

The aim of this study was to evaluate the effects of bilirubin- and/or everolimus (EVL)-coated stents to prevent arterial neointimal hyperplasia and inflammation in vitro and in vivo. The stents were prepared by spray coating bare metal stents (BMS) with bilirubin and/or EVL. Study groups were divid...

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Veröffentlicht in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2018-05, Vol.106 (4), p.1486-1495
Hauptverfasser: Bae, In-Ho, Park, Dae Sung, Lee, So-Youn, Jang, Eun-Jae, Shim, Jae-Won, Lim, Kyung-Seob, Park, Jun-Kyu, Kim, Ju Han, Sim, Doo Sun, Jeong, Myung Ho
Format: Artikel
Sprache:eng
Schlagworte:
Arteries
Bilirubin
Biomedical materials
Cell migration
Coating effects
Coatings
Commercialization
Computed tomography
Coronary artery
Drug delivery systems
Histopathology
Hyperplasia
Immunofluorescence
Implantation
Implants
Inflammation
Inflammatory response
Inhibitor drugs
Market shares
Materials research
Materials science
Muscles
Optical Coherence Tomography
Product development
Restenosis
Smooth muscle
Stents
Surgical implants
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Zusammenfassung:The aim of this study was to evaluate the effects of bilirubin- and/or everolimus (EVL)-coated stents to prevent arterial neointimal hyperplasia and inflammation in vitro and in vivo. The stents were prepared by spray coating bare metal stents (BMS) with bilirubin and/or EVL. Study groups were divided into (1) BMS, (2) bilirubin-coated stents (BES), (3) commercialized stents (Synergy™; EES), and (4) bilirubin/EVL-coated stents (B-EES). The coating thickness and drug release rates were comparable to previous reports (i.e.,
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.33955