High endocan levels are associated with the need for mechanical ventilation among patients with severe sepsis
Sepsis affects more than 750 000 Americans each year, with a mortality rate close to 30% [1]. A significant amount of resources has been put into improving our understanding of sepsis and developing new therapies. A push for early sepsis recognition and subsequent timely treatment has led to an inte...
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Veröffentlicht in: | The European respiratory journal 2017-07, Vol.50 (1), p.1700013-1700013 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Sepsis affects more than 750 000 Americans each year, with a mortality rate close to 30% [1]. A significant amount of resources has been put into improving our understanding of sepsis and developing new therapies. A push for early sepsis recognition and subsequent timely treatment has led to an interest in inflammatory biomarkers to identify sepsis and its severity [2]. Respiratory dysfunction occurs in up to 81% of cases and a significant proportion requires ventilatory support [1]. Studies have looked at a variety of biomarkers, from inflammatory cytokines such as interleukin (IL)-6 to endothelial proteins like intercellular adhesion molecule-1, to identify patients at greatest risk of developing respiratory compromise [3]. |
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ISSN: | 0903-1936 1399-3003 |
DOI: | 10.1183/13993003.00013-2017 |