Functional analysis of Discoidin domain receptor 2 mutation and expression in squamous cell lung cancer

Highlights • Endogenous DDR2 protein expression levels were high in 29% of lung SQCC patients. • A DDR2 mutation (T681I) identified in a lung SQCC clinical sample and the cell line. • Forced expression of DDR2 induced invasion in vitro and metastasis in animal model. • Ectopic expression of DDR2 ind...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2017-08, Vol.110, p.35-41
Hauptverfasser:	Kobayashi-Watanabe, Naomi, Sato, Akemi, Watanabe, Tatsuro, Abe, Tomonori, Nakashima, Chiho, Sueoka, Eisaburo, Kimura, Shinya, Sueoka-Aragane, Naoko
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Line, Tumor Cell Movement - genetics Cell Proliferation DDR2 Discoidin Domain Receptor 2 - genetics Discoidin Domain Receptor 2 - metabolism Disease Models, Animal Gene Expression Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung squamous cell carcinoma Male Matrix Metalloproteinase 1 - metabolism Mice MMP-1 Mutation Overexpression Phosphorylation Proto-Oncogene Proteins c-jun - metabolism Pulmonary/Respiratory
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Zusammenfassung:	Highlights • Endogenous DDR2 protein expression levels were high in 29% of lung SQCC patients. • A DDR2 mutation (T681I) identified in a lung SQCC clinical sample and the cell line. • Forced expression of DDR2 induced invasion in vitro and metastasis in animal model. • Ectopic expression of DDR2 induced MMP1 mRNA expression. 　　　　　　　　　 • T681I mutation seems to be an inactivating mutation.
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2017.05.017