FDG-PET/CT for response evaluation of invasive bladder cancer following neoadjuvant chemotherapy

FDG-PET/CT for response evaluation of invasive bladder cancer following neoadjuvant chemotherapy

Purpose We investigated the accuracy of FDG-PET/CT response identification following neoadjuvant or induction chemotherapy (NAIC) for invasive bladder cancer (BC) as to better select patients for radical cystectomy (RC). Methods Between 2010 and 2014, 37 cT1-4N1-3 BC patients received a FDG-PET/CT b...

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Veröffentlicht in:International urology and nephrology 2017-09, Vol.49 (9), p.1585-1591
Hauptverfasser: van de Putte, E. E. Fransen, Vegt, E., Mertens, L. S., Bruining, A., Hendricksen, K., van der Heijden, M. S., Horenblas, S., van Rhijn, B. W. G.
Format: Artikel
Sprache:eng
Schlagworte:
Bladder cancer
Cancer
Chemotherapy
Computed tomography
Diuresis
Invasiveness
Lymph
Lymph nodes
Medicine
Medicine & Public Health
Metabolism
Metastases
Nephrology
Pelvis
Polymerase chain reaction
Toxicity
Urinary bladder
Urology
Urology - Original Paper
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Zusammenfassung:Purpose We investigated the accuracy of FDG-PET/CT response identification following neoadjuvant or induction chemotherapy (NAIC) for invasive bladder cancer (BC) as to better select patients for radical cystectomy (RC). Methods Between 2010 and 2014, 37 cT1-4N1-3 BC patients received a FDG-PET/CT before and after NAIC followed by RC. Metabolic lymph node (LN) response was evaluated according to EORTC recommendations. Additionally, primary tumor response was evaluated for 23 patients by means of delayed pelvic imaging after forced diuresis. Gold standard was response on pathologic analysis of RC specimens. Response was defined as partial response (pPR, any pathologic downstaging) or complete response (pCR, 
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-017-1637-4