Quantitative in vivo imaging of tissue factor expression in glioma using dynamic contrast-enhanced MRI derived parameters

Highlights • Ktrans hot-spot and 90th percentile value could be biomarkers for TF expression. • Max relative frequency and skewness of Ktrans histogram characterize TF expression. • Functional status of the tumor neovasculature may explain the strong correlation.

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Bibliographische Detailangaben
Veröffentlicht in:	European journal of radiology 2017-08, Vol.93, p.236-242
Hauptverfasser:	Chen, Xiao, Xie, Tian, Fang, Jingqin, Xue, Wei, Tong, Haipeng, Kang, Houyi, Wang, Sumei, Yang, Yizeng, Xu, Minhui, Zhang, Weiguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Contrast Media Cross-Sectional Studies Female Glioma Glioma - blood supply Glioma - metabolism Glioma - pathology Humans In vivo Ktrans Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Middle Aged Neovascularization, Pathologic - pathology Prognosis Radiology Retrospective Studies Supratentorial Neoplasms - blood supply Supratentorial Neoplasms - metabolism Supratentorial Neoplasms - pathology Thromboplastin - metabolism Tissue factor
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Beschreibung
Zusammenfassung:	Highlights • Ktrans hot-spot and 90th percentile value could be biomarkers for TF expression. • Max relative frequency and skewness of Ktrans histogram characterize TF expression. • Functional status of the tumor neovasculature may explain the strong correlation.
ISSN:	0720-048X 1872-7727
DOI:	10.1016/j.ejrad.2017.06.006