Association of serum lipid levels over time with survival in incident peritoneal dialysis patients

Abstract Background Association of dyslipidemia with mortality has not been fully evaluated in patients on peritoneal dialysis (PD). Moreover, changes in lipids levels over time and associated death risk have not yet been studied in this population. Objective We studied the association of time-updated serum lipid concentrations with all-cause and cardiovascular (CV) mortality in a 10-year cohort of 749 incident PD patients. Methods Association was assessed using time-varying Cox proportional hazard regression models with adjustment for multiple variables including statin therapy. Results During a median follow-up of 36 (inter-quartile range, 21-61) months, 273 all-cause and 107 CV deaths occurred. Compared to those with total cholesterol (TC) of 180 to