Prognostic evaluation of ALIP and CD34 immunostaining in IPSS-R subgroups of myelodysplastic syndromes

In order to evaluate the prognostic value of abnormal localisation of immature precursors (ALIP) and CD34 immunostaining in myelodysplastic syndromes (MDS), bone marrow histopathological features in 187 MDS patients were retrospectively analysed and the prognostic significance of ALIP and CD34 immun...

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Veröffentlicht in:	Pathology 2017-08, Vol.49 (5), p.526-533
Hauptverfasser:	Xiong, Bei, Nie, Yanbo, Tang, Zehai, Xue, Mei, Zuo, Xuelan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antigens, CD34 - metabolism Bone Marrow - metabolism Bone Marrow - pathology Bone marrow biopsy Child Disease Progression Disease-Free Survival Female Humans leukaemia-free survival Male Middle Aged Multivariate Analysis myelodysplastic syndromes Myelodysplastic Syndromes - diagnosis Myelodysplastic Syndromes - metabolism Myelodysplastic Syndromes - pathology overall survival Prognosis Retrospective Studies Revised-International Prognostic Scoring System Survival Analysis Young Adult
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Zusammenfassung:	In order to evaluate the prognostic value of abnormal localisation of immature precursors (ALIP) and CD34 immunostaining in myelodysplastic syndromes (MDS), bone marrow histopathological features in 187 MDS patients were retrospectively analysed and the prognostic significance of ALIP and CD34 immunostaining on overall survival (OS) and progression to leukaemia-free survival (PFS) in total patients and different Revised-International Prognostic Scoring System (IPSS-R) subgroups were evaluated. In univariate analysis, age ≥60, ALIP, ≥5% CD34+ cells, CD34+ clusters and IPSS-R subgroups were associated with shorter OS (p = 0.027, p
ISSN:	0031-3025 1465-3931
DOI:	10.1016/j.pathol.2017.05.001