Prevalence of hidradenitis suppurativa among patients with Down syndrome: a population‐based cross‐sectional analysis

Summary Background Hidradenitis suppurativa (HS) has been linked to Down syndrome (DS). Objectives To determine whether patients with DS have a higher prevalence of HS, and whether the diagnosis of HS occurs at an earlier age for these patients. Methods A cross‐sectional analysis was performed for a population sample of 11 936 patients with DS and 16 813 290 patients without DS. The primary outcome was the diagnosis of HS. Systemized Nomenclature of Medicine–Clinical Terms were used to identify patients with DS and HS. We used logistic regression models and significant interaction terms to evaluate the relationship between DS and HS. We also compared the proportion of incident HS cases within 5‐year age groups to determine whether patients with DS had received an earlier diagnosis of HS. Results Prevalence of HS among patients with DS was 2·1%, compared with 0·3% for patients without DS (P