Redox-sensitive and hyaluronic acid functionalized liposomes for cytoplasmic drug delivery to osteosarcoma in animal models

This study aimed to develop redox-sensitive and CD44-targeted liposomes to improve chemotherapy of osteosarcoma. Cationic liposomes were prepared and stabilized with a novel detachable polyethylene glycol (PEG2000) conjugated with cholesterol through a bio-reducible disulfide linker (Chol-SS-mPEG)....

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Veröffentlicht in:	Journal of controlled release 2017-09, Vol.261, p.113-125
Hauptverfasser:	Chi, Yingying, Yin, Xuelei, Sun, Kaoxiang, Feng, Shuaishuai, Liu, Jinhu, Chen, Daquan, Guo, Chuanyou, Wu, Zimei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - pharmacokinetics Antibiotics, Antineoplastic - pharmacology Bone Neoplasms - drug therapy CD44 Cytoplasm - metabolism Doxorubicin - administration & dosage Doxorubicin - pharmacokinetics Doxorubicin - pharmacology Drug Delivery Systems Flow Cytometry GSH-responsive Humans Hyaluronan Receptors - metabolism Hyaluronic acid (HA) Hyaluronic Acid - chemistry Intracellular delivery Liposomes Liver - metabolism Long-circulation Male Mice Mice, Inbred BALB C Mice, Nude Microscopy, Confocal Osteosarcoma Osteosarcoma - drug therapy Osteosarcoma - metabolism Oxidation-Reduction PEG-detachment Polyethylene Glycols - chemistry Rats Rats, Sprague-Dawley Xenograft Model Antitumor Assays
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