Association of the Del1518 Promoter (rs3730485) Polymorphism in the MDM2 Gene with Breast Cancer in a Mexican Population

The gene plays an important role in tumorigenesis. The data on the promoter polymorphism in the gene have revealed associations with cancer. We examined the role of the polymorphism through a comparison of the genotypes of 345 healthy Mexican women with those of 742 Mexican women with breast cancer (BC). The genotype frequencies of the polymorphism in controls and patients with BC were 64% and 55.5% for , 32% and 31.5% for , and 4% and 13% for , respectively. The obtained odds ratio (OR) was 3.26, with a 95% confidence interval (95% CI) of 1.86-5.72 and =0.0001, for the genotype. An association was evident when we examined the distribution of the genotype in patients with elevated levels of transaminase SGPT (OR=2.268; 95% CI=1.40-3.65; =0.0001). Additionally, we observed an association of the genotypes in menopausal patients with BC with the following characteristics: tobacco consumption (OR = 1.93, 95% CI = 1.07-3.4, =0.025), pregnancy loss (OR=2.44, 95% CI=1.37-4.35, =0.0024), obesity (I-IV) (OR=1.8, 95% CI=1.1-2.9, = 0.018), and elevated serum glucose levels (OR=3.72, 95% CI=2.0-6.85, =0.0001). The polymorphism was associated with BC susceptibility, particularly in menopausal patients with BC who reported tobacco consumption, pregnancy loss, obesity and high glucose levels in the analyzed Mexican population.