A study of clinical and physiological relations of daily physical activity in precapillary pulmonary hypertension
Daily physical activity is reduced in precapillary pulmonary hypertension (PH), but the underlying mechanisms are inadequately explored. We sought to investigate clinical and physiological relations of daily physical activity and profile differences between less and more active patients with precapi...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2017-10, Vol.123 (4), p.851-859 |
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| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Daily physical activity is reduced in precapillary pulmonary hypertension (PH), but the underlying mechanisms are inadequately explored. We sought to investigate clinical and physiological relations of daily physical activity and profile differences between less and more active patients with precapillary PH. A prospective, cross-sectional study of 20 patients with precapillary PH who undertook
) a comprehensive clinical assessment,
) a preliminary treadmill test,
) 7-day monitoring of daily walking intensity with triaxial accelerometry, and
) a personalized treadmill test corresponding to the individual patient mean daily walking intensity with real-time physiological measurements. Significant clinical correlations with individual patient mean walking intensity [1.71 ± 0.27 (SD) m/s
] were observed for log-transformed N-terminal probrain natriuretic peptide (log NT-proBNP;
= -0.75,
= |
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| ISSN: | 8750-7587 1522-1601 |
| DOI: | 10.1152/japplphysiol.00986.2016 |