Construction of pyrazolo[5,1-a]isoindol-8(3aH)-one derivatives via phosphine-catalyzed cyclization of electron-deficient alkynes and N-amino substituted phthalimide

Construction of pyrazolo[5,1-a]isoindol-8(3aH)-one derivatives via phosphine-catalyzed cyclization of electron-deficient alkynes and N-amino substituted phthalimide

A novel method for the synthesis of diversely functionalized pyrazolo[5,1- a ]isoindol-8(3 aH )-ones is developed via phosphine-catalyzed tandem Michael addition/intramolecular Morita–Baylis–Hillman reaction of electron-deficient alkynes and N -amino substituted phthalimide. This cyclization is oper...

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Veröffentlicht in:RSC advances 2016-01, Vol.6 (2), p.1395-1402
Hauptverfasser: Zhou, Qing-Fa, Ge, Fei-Fei, Chen, Qing-Qing, Lu, Tao
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes
Cascade chemical reactions
Derivatives
Phthalimides
Synthesis (chemistry)
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Zusammenfassung:A novel method for the synthesis of diversely functionalized pyrazolo[5,1- a ]isoindol-8(3 aH )-ones is developed via phosphine-catalyzed tandem Michael addition/intramolecular Morita–Baylis–Hillman reaction of electron-deficient alkynes and N -amino substituted phthalimide. This cyclization is operationally simple under metal-free reaction conditions.
ISSN:2046-2069
2046-2069
DOI:10.1039/C5RA17267E