Gold-catalyzed diastereoselective domino dearomatization/ipso-cyclization/aza-Michael sequence: a facile access to diverse fused azaspiro tetracyclic scaffolds

Gold-catalyzed diastereoselective domino dearomatization/ipso-cyclization/aza-Michael sequence: a facile access to diverse fused azaspiro tetracyclic scaffolds

A facile and diversity-oriented access to complex tetracyclic benzo[e]pyrrolo[2,3-c]indole-2,4,7(5H)-triones through a post-Ugi gold(i)-catalyzed domino dearomatization/ipso-cyclization/aza-Michael sequence is elaborated. This process furnishes tetracyclic scaffolds in good yields from readily avail...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2017, Vol.53 (48), p.6413-6416
Hauptverfasser: He, Yi, Li, Zhenghua, Tian, Guilong, Song, Liangliang, Van Meervelt, Luc, Van der Eycken, Erik V
Format: Artikel
Sprache:eng
Schlagworte:
Precursors
Scaffolds
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Zusammenfassung:A facile and diversity-oriented access to complex tetracyclic benzo[e]pyrrolo[2,3-c]indole-2,4,7(5H)-triones through a post-Ugi gold(i)-catalyzed domino dearomatization/ipso-cyclization/aza-Michael sequence is elaborated. This process furnishes tetracyclic scaffolds in good yields from readily available precursors with unique diastereoselectivity.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc03152a