Increased hepatic ABCA1 transporter is associated with hypercholesterolemia in a cholestatic rat model and primary biliary cholangitis patients

Hepatic ATP-binding cassette A1 (ABCA1) transporter is the modulator of intrahepatic cholesterol levels via the efflux of cholesterol into plasma. This study aimed to determine the expression of hepatic ABCA1 levels in a cholestatic rat model and patients with primary biliary cholangitis (PBC). A ch...

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Veröffentlicht in:	Medical molecular morphology 2017-12, Vol.50 (4), p.227-237
Hauptverfasser:	Takeyama, Yasuaki, Uehara, Yuko, Anan, Akira, Morihara, Daisuke, Yokoyama, Keiji, Takata, Kazuhide, Tanaka, Takashi, Irie, Makoto, Iwata, Kaoru, Shakado, Satoshi, Sohda, Tetsuro, Sakisaka, Shotaro
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCA1 protein Anatomy Animals ATP Binding Cassette Transporter 1 - antagonists & inhibitors ATP Binding Cassette Transporter 1 - genetics ATP Binding Cassette Transporter 1 - metabolism ATP-binding protein Bile Biological Transport Cell Line, Tumor Cholangitis Cholestasis Cholestasis, Intrahepatic - genetics Cholestasis, Intrahepatic - metabolism Cholestasis, Intrahepatic - pathology Cholesterol Cholesterol - metabolism Disease Models, Animal Gene expression Gene Expression Regulation Hepatocytes - metabolism Hepatocytes - pathology Humans Hypercholesterolemia Hypercholesterolemia - genetics Hypercholesterolemia - metabolism Hypercholesterolemia - pathology Liver Liver - metabolism Liver - pathology Liver Cirrhosis, Biliary - genetics Liver Cirrhosis, Biliary - metabolism Liver Cirrhosis, Biliary - pathology Liver X receptors Liver X Receptors - genetics Liver X Receptors - metabolism Male Medicine Medicine & Public Health Molecular Medicine mRNA Original Paper Pathology Rats Rats, Wistar RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Rodents Signal Transduction siRNA
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Zusammenfassung:	Hepatic ATP-binding cassette A1 (ABCA1) transporter is the modulator of intrahepatic cholesterol levels via the efflux of cholesterol into plasma. This study aimed to determine the expression of hepatic ABCA1 levels in a cholestatic rat model and patients with primary biliary cholangitis (PBC). A cholesterol efflux study was conducted with Abca1 knock down using siRNA in WIF9 cells. Cholesterol levels in the ABCA1 siRNA cells in the medium were significantly decreased compared with those in controls ( P
ISSN:	1860-1480 1860-1499
DOI:	10.1007/s00795-017-0166-7