FKBP5 Moderation of the Relationship between Childhood Trauma and Maladaptive Emotion Regulation Strategies in Adolescents

Highlights • This study examined the G × E on transdiagnostic risk factors of psychopathology. • FKBP5 × childhood trauma predicted rumination and catastrophizing in adolescents. • CATT carriers exposed to trauma endorsed the highest rumination and catastrophizing. • Findings suggest mechanisms for...

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Veröffentlicht in:	Psychoneuroendocrinology 2017-10, Vol.84, p.61-65
Hauptverfasser:	Halldorsdottir, Thorhildur, de Matos, Ana Paula Soares, Awaloff, Yvonne, Arnarson, Eiríkur Örn, Craighead, W. Edward, Binder, Elisabeth B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adolescents Adult Survivors of Child Abuse - psychology Catastrophization - genetics Catastrophization - psychology Catastrophizing Childhood trauma Emotions - physiology Endocrinology & Metabolism Female FKBP5 Gene-Environment Interaction Genetic Variation Genotype Haplotypes - genetics Humans Life Change Events Linkage Disequilibrium Male Polymorphism, Single Nucleotide Psychiatry Psychopathology - methods Risk Factors Rumination Rumination, Cognitive - physiology Tacrolimus Binding Proteins - genetics Tacrolimus Binding Proteins - metabolism
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Zusammenfassung:	Highlights • This study examined the G × E on transdiagnostic risk factors of psychopathology. • FKBP5 × childhood trauma predicted rumination and catastrophizing in adolescents. • CATT carriers exposed to trauma endorsed the highest rumination and catastrophizing. • Findings suggest mechanisms for the vulnerability of CATT carriers to psychopathology
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2017.06.012