A review of high performance liquid chromatographic-mass spectrometric urinary methods for anticancer drug exposure of health care workers
•Review of HPLC–MS/MS methods for quantitation of anticancer drugs in urine.•Includes drugs, isomers, drug metabolites and simultaneous multi-drug determinations.•Tabular summaries of method sample preparation, LC parameters, and MS detection modes.•Presents comparative overview of methods, their de...
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| Veröffentlicht in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2017-08, Vol.1060, p.316-324 |
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| container_title | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |
| container_volume | 1060 |
| creator | Mathias, Patricia I. Connor, Thomas H. B’Hymer, Clayton |
| description | •Review of HPLC–MS/MS methods for quantitation of anticancer drugs in urine.•Includes drugs, isomers, drug metabolites and simultaneous multi-drug determinations.•Tabular summaries of method sample preparation, LC parameters, and MS detection modes.•Presents comparative overview of methods, their development, and validation protocols.•Discussion of future trends including UHPLC–MS/MS and simultaneous multi-drug methods.
This review describes published high performance liquid chromatography/mass spectrometry (HPLC–MS) methods for the determination of anticancer drugs in human urine as non-invasive tool for monitoring of health care worker exposure to antineoplastic and cytotoxic drugs. HPLC–MS is a sensitive and specific method for analysis of anticancer drugs and their metabolites in biological fluids. In this review, a tabular summary and overview of published HPLC–MS methods are presented, as well as future trends and limitations in this area of research. |
| doi_str_mv | 10.1016/j.jchromb.2017.06.028 |
| format | Article |
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This review describes published high performance liquid chromatography/mass spectrometry (HPLC–MS) methods for the determination of anticancer drugs in human urine as non-invasive tool for monitoring of health care worker exposure to antineoplastic and cytotoxic drugs. HPLC–MS is a sensitive and specific method for analysis of anticancer drugs and their metabolites in biological fluids. In this review, a tabular summary and overview of published HPLC–MS methods are presented, as well as future trends and limitations in this area of research.</description><identifier>ISSN: 1570-0232</identifier><identifier>EISSN: 1873-376X</identifier><identifier>DOI: 10.1016/j.jchromb.2017.06.028</identifier><identifier>PMID: 28654869</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Anticancer drugs ; Antineoplastic Agents - urine ; Antineoplastic drug ; Biomarkers - urine ; Chromatography, High Pressure Liquid - methods ; Health Personnel ; Humans ; Liquid chromatography mass spectrometry ; Mass Spectrometry - methods ; Occupational biomonitoring ; Occupational Exposure - analysis ; Urinary biomarker</subject><ispartof>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2017-08, Vol.1060, p.316-324</ispartof><rights>2017</rights><rights>Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-3d9afffe7cb7e9ec013515e883a1182bf24ebb6c25991ad7a113159b458aa21d3</citedby><cites>FETCH-LOGICAL-c478t-3d9afffe7cb7e9ec013515e883a1182bf24ebb6c25991ad7a113159b458aa21d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jchromb.2017.06.028$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28654869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mathias, Patricia I.</creatorcontrib><creatorcontrib>Connor, Thomas H.</creatorcontrib><creatorcontrib>B’Hymer, Clayton</creatorcontrib><title>A review of high performance liquid chromatographic-mass spectrometric urinary methods for anticancer drug exposure of health care workers</title><title>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</title><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><description>•Review of HPLC–MS/MS methods for quantitation of anticancer drugs in urine.•Includes drugs, isomers, drug metabolites and simultaneous multi-drug determinations.•Tabular summaries of method sample preparation, LC parameters, and MS detection modes.•Presents comparative overview of methods, their development, and validation protocols.•Discussion of future trends including UHPLC–MS/MS and simultaneous multi-drug methods.
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| identifier | ISSN: 1570-0232 |
| ispartof | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2017-08, Vol.1060, p.316-324 |
| issn | 1570-0232 1873-376X |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Anticancer drugs Antineoplastic Agents - urine Antineoplastic drug Biomarkers - urine Chromatography, High Pressure Liquid - methods Health Personnel Humans Liquid chromatography mass spectrometry Mass Spectrometry - methods Occupational biomonitoring Occupational Exposure - analysis Urinary biomarker |
| title | A review of high performance liquid chromatographic-mass spectrometric urinary methods for anticancer drug exposure of health care workers |
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