A zinc oxide‐modified hydroxyapatite‐based cement facilitated new crystalline‐stoichiometric and amorphous apatite precipitation on dentine
Aim To evaluate the remineralization ability of two endodontic sealer cements. Methodology Mid‐coronal dentine surfaces were subjected to: (i) 37% phosphoric acid (PA) or (ii) 0.5 mol L−1 ethylenediaminetetraacetic acid (EDTA) conditioning prior to the application of two experimental hydroxyapatite‐...
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| Veröffentlicht in: | International endodontic journal 2017-12, Vol.50 (S2), p.e109-e119 |
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| creator | Toledano, M. Pérez‐Álvarez, M. C. Aguilera, F. S. Osorio, E. Cabello, I. Toledano‐Osorio, M. Osorio, R. |
| description | Aim
To evaluate the remineralization ability of two endodontic sealer cements.
Methodology
Mid‐coronal dentine surfaces were subjected to: (i) 37% phosphoric acid (PA) or (ii) 0.5 mol L−1 ethylenediaminetetraacetic acid (EDTA) conditioning prior to the application of two experimental hydroxyapatite‐based cements, containing sodium hydroxide (calcypatite) or zinc oxide oxiapatite respectively. Samples were stored in simulated body fluid for 24 h or 21 days. Remineralization of the dentine surfaces were studied by Raman spectroscopy (mapping with K‐means cluster and hierarchical cluster analysis) was undertaken. Nanoroughness and collagen fibril width measurements were performed with an atomic force microscopy. ANOVA and Student–Newman–Keuls test were performed (α=0.05).
Results
Phosphoric acid+oxiapatite promoted both the highest dentine mineralization (P |
| doi_str_mv | 10.1111/iej.12807 |
| format | Article |
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To evaluate the remineralization ability of two endodontic sealer cements.
Methodology
Mid‐coronal dentine surfaces were subjected to: (i) 37% phosphoric acid (PA) or (ii) 0.5 mol L−1 ethylenediaminetetraacetic acid (EDTA) conditioning prior to the application of two experimental hydroxyapatite‐based cements, containing sodium hydroxide (calcypatite) or zinc oxide oxiapatite respectively. Samples were stored in simulated body fluid for 24 h or 21 days. Remineralization of the dentine surfaces were studied by Raman spectroscopy (mapping with K‐means cluster and hierarchical cluster analysis) was undertaken. Nanoroughness and collagen fibril width measurements were performed with an atomic force microscopy. ANOVA and Student–Newman–Keuls test were performed (α=0.05).
Results
Phosphoric acid+oxiapatite promoted both the highest dentine mineralization (P < 0.05) and crystallographic maturity at the dentine surface. Noncrystalline amorphous‐like apatites were also formed. Dentine treated with PA+calcypatite attained the roughest surface (P < 0.05) with minimal fibril width (P < 0.05). Cross‐linking of collagen only became greater in the group PA+oxiapatite after 21 days. The maximum relative mineral concentration and structure of collagen linked to the amide I and ratio amide III/AGEs was obtained after using PA+calcypatite at 21‐days time‐point (P < 0.05). EDTA produced a lower stoichiometric hydroxyapatite (P < 0.05) with decreased maturity, at the expense of carbonate band widening, although it favoured the nucleation of carbonated calcium phosphate.
Conclusions
Dentine surfaces treated with PA+oxiapatite attained the highest dentine remineralization with both crystalline‐stoichiometric and amorphous apatites, at 21 days. EDTA conditioning facilitated amorphous‐bulk mineral precipitation. The amorphization was more intense after using oxiapatite and provided an ion‐rich environment favouring in situ dentine remineralization.</description><identifier>ISSN: 0143-2885</identifier><identifier>EISSN: 1365-2591</identifier><identifier>DOI: 10.1111/iej.12807</identifier><identifier>PMID: 28653756</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Acetic acid ; Apatite ; Atomic force microscopy ; Calcium phosphates ; Chemical precipitation ; Cluster analysis ; Collagen ; Cross-linking ; crystallinity ; Dental Cements - chemistry ; Dentin - chemistry ; dentine ; Dentistry ; Edetic acid ; Endodontics ; Hydroxyapatite ; Hydroxyapatites - chemistry ; Materials Testing ; Mineralization ; Phosphoric acid ; Phosphoric Acids ; Raman ; Raman spectroscopy ; Remineralization ; Sodium ; Sodium hydroxide ; Spectroscopy ; Spectrum Analysis, Raman ; Surface Properties ; Tooth Remineralization ; zinc ; Zinc oxide ; Zinc Oxide - chemistry ; Zinc oxides</subject><ispartof>International endodontic journal, 2017-12, Vol.50 (S2), p.e109-e119</ispartof><rights>2017 International Endodontic Journal. Published by John Wiley & Sons Ltd</rights><rights>2017 International Endodontic Journal. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 International Endodontic Journal. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3887-61068b31a750bae5b6710124df562ce1be17033f40da688cbea140132c2a30d83</citedby><cites>FETCH-LOGICAL-c3887-61068b31a750bae5b6710124df562ce1be17033f40da688cbea140132c2a30d83</cites><orcidid>0000-0002-2172-7896</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fiej.12807$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fiej.12807$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28653756$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Toledano, M.</creatorcontrib><creatorcontrib>Pérez‐Álvarez, M. C.</creatorcontrib><creatorcontrib>Aguilera, F. S.</creatorcontrib><creatorcontrib>Osorio, E.</creatorcontrib><creatorcontrib>Cabello, I.</creatorcontrib><creatorcontrib>Toledano‐Osorio, M.</creatorcontrib><creatorcontrib>Osorio, R.</creatorcontrib><title>A zinc oxide‐modified hydroxyapatite‐based cement facilitated new crystalline‐stoichiometric and amorphous apatite precipitation on dentine</title><title>International endodontic journal</title><addtitle>Int Endod J</addtitle><description>Aim
To evaluate the remineralization ability of two endodontic sealer cements.
Methodology
Mid‐coronal dentine surfaces were subjected to: (i) 37% phosphoric acid (PA) or (ii) 0.5 mol L−1 ethylenediaminetetraacetic acid (EDTA) conditioning prior to the application of two experimental hydroxyapatite‐based cements, containing sodium hydroxide (calcypatite) or zinc oxide oxiapatite respectively. Samples were stored in simulated body fluid for 24 h or 21 days. Remineralization of the dentine surfaces were studied by Raman spectroscopy (mapping with K‐means cluster and hierarchical cluster analysis) was undertaken. Nanoroughness and collagen fibril width measurements were performed with an atomic force microscopy. ANOVA and Student–Newman–Keuls test were performed (α=0.05).
Results
Phosphoric acid+oxiapatite promoted both the highest dentine mineralization (P < 0.05) and crystallographic maturity at the dentine surface. Noncrystalline amorphous‐like apatites were also formed. Dentine treated with PA+calcypatite attained the roughest surface (P < 0.05) with minimal fibril width (P < 0.05). Cross‐linking of collagen only became greater in the group PA+oxiapatite after 21 days. The maximum relative mineral concentration and structure of collagen linked to the amide I and ratio amide III/AGEs was obtained after using PA+calcypatite at 21‐days time‐point (P < 0.05). EDTA produced a lower stoichiometric hydroxyapatite (P < 0.05) with decreased maturity, at the expense of carbonate band widening, although it favoured the nucleation of carbonated calcium phosphate.
Conclusions
Dentine surfaces treated with PA+oxiapatite attained the highest dentine remineralization with both crystalline‐stoichiometric and amorphous apatites, at 21 days. EDTA conditioning facilitated amorphous‐bulk mineral precipitation. The amorphization was more intense after using oxiapatite and provided an ion‐rich environment favouring in situ dentine remineralization.</description><subject>Acetic acid</subject><subject>Apatite</subject><subject>Atomic force microscopy</subject><subject>Calcium phosphates</subject><subject>Chemical precipitation</subject><subject>Cluster analysis</subject><subject>Collagen</subject><subject>Cross-linking</subject><subject>crystallinity</subject><subject>Dental Cements - chemistry</subject><subject>Dentin - chemistry</subject><subject>dentine</subject><subject>Dentistry</subject><subject>Edetic acid</subject><subject>Endodontics</subject><subject>Hydroxyapatite</subject><subject>Hydroxyapatites - chemistry</subject><subject>Materials Testing</subject><subject>Mineralization</subject><subject>Phosphoric acid</subject><subject>Phosphoric Acids</subject><subject>Raman</subject><subject>Raman spectroscopy</subject><subject>Remineralization</subject><subject>Sodium</subject><subject>Sodium hydroxide</subject><subject>Spectroscopy</subject><subject>Spectrum Analysis, Raman</subject><subject>Surface Properties</subject><subject>Tooth Remineralization</subject><subject>zinc</subject><subject>Zinc oxide</subject><subject>Zinc Oxide - chemistry</subject><subject>Zinc oxides</subject><issn>0143-2885</issn><issn>1365-2591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcGKFDEQhoMo7jh68AUk4EUPvZtKOunMcVlWXVnwoucmnVQzGbo7bZJht_fkI-gr-iRmnNGDYAgEqr58FPUT8hLYOZRz4XF3Dlyz5hFZgVCy4nIDj8mKQS0qrrU8I89S2jHGJBPwlJxxraRopFqRH5f0wU-Whnvv8Oe372Nwvvfo6HZxMdwvZjbZ50OnM6mULY44Zdob6wefTS6lCe-ojUvKZhj8dEBTDt5ufRgxR2-pmRw1Y4jzNuwTPRnpHNH6-eDwYaLluiIu_5-TJ70ZEr44vWvy5d3156sP1e2n9zdXl7eVFVo3lQKmdCfANJJ1BmWnGmDAa9dLxS1Ch9AwIfqaOaO0th0aqBkIbrkRzGmxJm-O3jmGr3tMuR19sjgMZsIyZwsbqPkGdNnhmrz-B92FfZzKdIVSqtFlxaxQb4-UjSGliH07Rz-auLTA2kNObcmp_Z1TYV-djPtuRPeX_BNMAS6OwJ0fcPm_qb25_nhU_gLgn6IL</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Toledano, M.</creator><creator>Pérez‐Álvarez, M. C.</creator><creator>Aguilera, F. S.</creator><creator>Osorio, E.</creator><creator>Cabello, I.</creator><creator>Toledano‐Osorio, M.</creator><creator>Osorio, R.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2172-7896</orcidid></search><sort><creationdate>201712</creationdate><title>A zinc oxide‐modified hydroxyapatite‐based cement facilitated new crystalline‐stoichiometric and amorphous apatite precipitation on dentine</title><author>Toledano, M. ; Pérez‐Álvarez, M. C. ; Aguilera, F. S. ; Osorio, E. ; Cabello, I. ; Toledano‐Osorio, M. ; Osorio, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3887-61068b31a750bae5b6710124df562ce1be17033f40da688cbea140132c2a30d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acetic acid</topic><topic>Apatite</topic><topic>Atomic force microscopy</topic><topic>Calcium phosphates</topic><topic>Chemical precipitation</topic><topic>Cluster analysis</topic><topic>Collagen</topic><topic>Cross-linking</topic><topic>crystallinity</topic><topic>Dental Cements - chemistry</topic><topic>Dentin - chemistry</topic><topic>dentine</topic><topic>Dentistry</topic><topic>Edetic acid</topic><topic>Endodontics</topic><topic>Hydroxyapatite</topic><topic>Hydroxyapatites - chemistry</topic><topic>Materials Testing</topic><topic>Mineralization</topic><topic>Phosphoric acid</topic><topic>Phosphoric Acids</topic><topic>Raman</topic><topic>Raman spectroscopy</topic><topic>Remineralization</topic><topic>Sodium</topic><topic>Sodium hydroxide</topic><topic>Spectroscopy</topic><topic>Spectrum Analysis, Raman</topic><topic>Surface Properties</topic><topic>Tooth Remineralization</topic><topic>zinc</topic><topic>Zinc oxide</topic><topic>Zinc Oxide - chemistry</topic><topic>Zinc oxides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Toledano, M.</creatorcontrib><creatorcontrib>Pérez‐Álvarez, M. C.</creatorcontrib><creatorcontrib>Aguilera, F. S.</creatorcontrib><creatorcontrib>Osorio, E.</creatorcontrib><creatorcontrib>Cabello, I.</creatorcontrib><creatorcontrib>Toledano‐Osorio, M.</creatorcontrib><creatorcontrib>Osorio, R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International endodontic journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Toledano, M.</au><au>Pérez‐Álvarez, M. C.</au><au>Aguilera, F. S.</au><au>Osorio, E.</au><au>Cabello, I.</au><au>Toledano‐Osorio, M.</au><au>Osorio, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A zinc oxide‐modified hydroxyapatite‐based cement facilitated new crystalline‐stoichiometric and amorphous apatite precipitation on dentine</atitle><jtitle>International endodontic journal</jtitle><addtitle>Int Endod J</addtitle><date>2017-12</date><risdate>2017</risdate><volume>50</volume><issue>S2</issue><spage>e109</spage><epage>e119</epage><pages>e109-e119</pages><issn>0143-2885</issn><eissn>1365-2591</eissn><abstract>Aim
To evaluate the remineralization ability of two endodontic sealer cements.
Methodology
Mid‐coronal dentine surfaces were subjected to: (i) 37% phosphoric acid (PA) or (ii) 0.5 mol L−1 ethylenediaminetetraacetic acid (EDTA) conditioning prior to the application of two experimental hydroxyapatite‐based cements, containing sodium hydroxide (calcypatite) or zinc oxide oxiapatite respectively. Samples were stored in simulated body fluid for 24 h or 21 days. Remineralization of the dentine surfaces were studied by Raman spectroscopy (mapping with K‐means cluster and hierarchical cluster analysis) was undertaken. Nanoroughness and collagen fibril width measurements were performed with an atomic force microscopy. ANOVA and Student–Newman–Keuls test were performed (α=0.05).
Results
Phosphoric acid+oxiapatite promoted both the highest dentine mineralization (P < 0.05) and crystallographic maturity at the dentine surface. Noncrystalline amorphous‐like apatites were also formed. Dentine treated with PA+calcypatite attained the roughest surface (P < 0.05) with minimal fibril width (P < 0.05). Cross‐linking of collagen only became greater in the group PA+oxiapatite after 21 days. The maximum relative mineral concentration and structure of collagen linked to the amide I and ratio amide III/AGEs was obtained after using PA+calcypatite at 21‐days time‐point (P < 0.05). EDTA produced a lower stoichiometric hydroxyapatite (P < 0.05) with decreased maturity, at the expense of carbonate band widening, although it favoured the nucleation of carbonated calcium phosphate.
Conclusions
Dentine surfaces treated with PA+oxiapatite attained the highest dentine remineralization with both crystalline‐stoichiometric and amorphous apatites, at 21 days. EDTA conditioning facilitated amorphous‐bulk mineral precipitation. The amorphization was more intense after using oxiapatite and provided an ion‐rich environment favouring in situ dentine remineralization.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28653756</pmid><doi>10.1111/iej.12807</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2172-7896</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0143-2885 |
| ispartof | International endodontic journal, 2017-12, Vol.50 (S2), p.e109-e119 |
| issn | 0143-2885 1365-2591 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Acetic acid Apatite Atomic force microscopy Calcium phosphates Chemical precipitation Cluster analysis Collagen Cross-linking crystallinity Dental Cements - chemistry Dentin - chemistry dentine Dentistry Edetic acid Endodontics Hydroxyapatite Hydroxyapatites - chemistry Materials Testing Mineralization Phosphoric acid Phosphoric Acids Raman Raman spectroscopy Remineralization Sodium Sodium hydroxide Spectroscopy Spectrum Analysis, Raman Surface Properties Tooth Remineralization zinc Zinc oxide Zinc Oxide - chemistry Zinc oxides |
| title | A zinc oxide‐modified hydroxyapatite‐based cement facilitated new crystalline‐stoichiometric and amorphous apatite precipitation on dentine |
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