Spongian Diterpenes from the Sponge Hyattella aff. intestinalis

Extracts of the sponge Hyattella aff. intestinalis showed moderate inhibition against adenovirus. Chromatographic separation of the extracts followed by analysis of spectroscopic data allowed us to elucidate the structures of three new metabolites as 2α-hydroxyspongia-13(16),14-diene-3-one (4), 3β-h...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2017/09/01, Vol.65(9), pp.874-877
Hauptverfasser:	Ahmadi, Peni, Haruyama, Takahiro, Kobayashi, Nobuyuki, Voogd, Nicole Joy de, Tanaka, Junichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - drug effects adenovirus Animals antiviral Antiviral activity Antiviral Agents - chemistry Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Cell Line, Tumor Cell Survival - drug effects cytotoxicity Data processing Diterpenes Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Inhibitory Concentration 50 Magnetic Resonance Spectroscopy Metabolites Molecular Conformation Porifera - chemistry Porifera - metabolism Rats sponge spongian diterpene
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Zusammenfassung:	Extracts of the sponge Hyattella aff. intestinalis showed moderate inhibition against adenovirus. Chromatographic separation of the extracts followed by analysis of spectroscopic data allowed us to elucidate the structures of three new metabolites as 2α-hydroxyspongia-13(16),14-diene-3-one (4), 3β-hydroxyspongia-13(16),14-diene-2-one (7), and 2α,3α-diacetoxy-17,19-dihydroxyspongia-13(16),14-diene (8) and to identify six known ones 1–3, 5, 6 and 9. Among the molecules, compounds 1 and 3 showed antiviral activity at IC50 17.0 and 52.0 µM.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.c17-00297