In vitro stimulation of vitellogenin expression by insulin in the mud crab, Scylla paramamosain , mediated through PI3K/Akt/TOR pathway
Highlights • The hepatopancreas is the major site of Sp-vtg synthesis in S. paramamosain. • Key factors in ILP signaling are conserved in S. paramamosain. • Knockdown of Sp-Akt blocks the stimulation of Sp-vtg expression by insulin. • Inhibitors of PI3K and TOR block the stimulation of Sp-vtg expres...
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| Veröffentlicht in: | General and comparative endocrinology 2017-09, Vol.250, p.175-180 |
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| container_title | General and comparative endocrinology |
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| creator | Huang, Xiaoshuai Feng, Biyun Huang, Huiyang Ye, Haihui |
| description | Highlights • The hepatopancreas is the major site of Sp-vtg synthesis in S. paramamosain. • Key factors in ILP signaling are conserved in S. paramamosain. • Knockdown of Sp-Akt blocks the stimulation of Sp-vtg expression by insulin. • Inhibitors of PI3K and TOR block the stimulation of Sp-vtg expression by insulin. |
| doi_str_mv | 10.1016/j.ygcen.2017.06.013 |
| format | Article |
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| ispartof | General and comparative endocrinology, 2017-09, Vol.250, p.175-180 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Brachyura - drug effects Brachyura - metabolism Cattle DNA, Complementary - genetics Endocrinology & Metabolism Female Gene Knockdown Techniques Hepatopancreas - drug effects Hepatopancreas - metabolism In vitro experiments Insulin - pharmacology Insulin-like peptide Peptides - metabolism Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism RNAi Scylla paramamosain Signal Transduction - drug effects TOR Serine-Threonine Kinases - metabolism Vitellogenin Vitellogenins - metabolism |
| title | In vitro stimulation of vitellogenin expression by insulin in the mud crab, Scylla paramamosain , mediated through PI3K/Akt/TOR pathway |
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