In vitro stimulation of vitellogenin expression by insulin in the mud crab, Scylla paramamosain , mediated through PI3K/Akt/TOR pathway

Highlights • The hepatopancreas is the major site of Sp-vtg synthesis in S. paramamosain. • Key factors in ILP signaling are conserved in S. paramamosain. • Knockdown of Sp-Akt blocks the stimulation of Sp-vtg expression by insulin. • Inhibitors of PI3K and TOR block the stimulation of Sp-vtg expres...

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Veröffentlicht in:	General and comparative endocrinology 2017-09, Vol.250, p.175-180
Hauptverfasser:	Huang, Xiaoshuai, Feng, Biyun, Huang, Huiyang, Ye, Haihui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brachyura - drug effects Brachyura - metabolism Cattle DNA, Complementary - genetics Endocrinology & Metabolism Female Gene Knockdown Techniques Hepatopancreas - drug effects Hepatopancreas - metabolism In vitro experiments Insulin - pharmacology Insulin-like peptide Peptides - metabolism Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism RNAi Scylla paramamosain Signal Transduction - drug effects TOR Serine-Threonine Kinases - metabolism Vitellogenin Vitellogenins - metabolism
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Zusammenfassung:	Highlights • The hepatopancreas is the major site of Sp-vtg synthesis in S. paramamosain. • Key factors in ILP signaling are conserved in S. paramamosain. • Knockdown of Sp-Akt blocks the stimulation of Sp-vtg expression by insulin. • Inhibitors of PI3K and TOR block the stimulation of Sp-vtg expression by insulin.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2017.06.013