Expression of p63 and CD44 in oral squamous cell carcinoma and correlation with clinicopathological parameters

Highlights • The rate of mortality and morbidity for OSCC patients has not been improved markedly. • Efficient targeting of CSCs is important for monitoring the progression of cancers. • Clinicopathological parameters and biomarkers expression in OSCC are evaluated. • Overexpression of CD44 and p63...

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Veröffentlicht in:	Archives of oral biology 2017-10, Vol.82, p.160-165
Hauptverfasser:	Saghravanian, Nasrollah, Anvari, Kazem, Ghazi, Narges, Memar, Bahram, Shahsavari, Maryam, Aghaee, Monavar Afzal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Advanced Basic Science Aged Aged, 80 and over Biomarkers, Tumor - metabolism Cancer stem cell Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology CD44 Dentistry Female Humans Hyaluronan Receptors - metabolism Immunoenzyme Techniques Male Middle Aged Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Neoplasm Staging p63 Prognosis Squamous cell carcinoma Transcription Factors - metabolism Tumor Suppressor Proteins - metabolism
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Zusammenfassung:	Highlights • The rate of mortality and morbidity for OSCC patients has not been improved markedly. • Efficient targeting of CSCs is important for monitoring the progression of cancers. • Clinicopathological parameters and biomarkers expression in OSCC are evaluated. • Overexpression of CD44 and p63 was associated with higher stage and grade of disease.
ISSN:	0003-9969 1879-1506
DOI:	10.1016/j.archoralbio.2017.06.011