Proteomic profiling of extracellular vesicles secreted from Toxoplasma gondii

Toxoplasma gondii infects a wide range of hosts worldwide, including humans and domesticated animals causing toxoplasmosis disease. Recently, exosomes, small extracellular vesicles (EV) that contain nucleic acids, proteins, and lipids derived from their original cells were linked with disease protec...

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Veröffentlicht in:	Proteomics (Weinheim) 2017-08, Vol.17 (15-16), p.1600477-n/a
Hauptverfasser:	Wowk, Pryscilla Fanini, Zardo, Maria Luisa, Miot, Halisson Tesseroli, Goldenberg, Samuel, Carvalho, Paulo Costa, Mörking, Patricia Alves
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal diseases Cell Line Domestic animals Exosomes Exosomes - metabolism Extracellular vesicles Extracellular Vesicles - metabolism Fibroblasts - cytology Fibroblasts - metabolism Fibroblasts - parasitology Foreskin - cytology Foreskin - metabolism Foreskin - parasitology Humans Immune response Immune system Lipids Male Nucleic acids Proteins Proteomics - methods Protozoa Toxoplasma - metabolism Toxoplasma gondii Toxoplasma‐infected cell Toxoplasmosis Toxoplasmosis - metabolism Toxoplasmosis - parasitology Vesicles
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Beschreibung
Zusammenfassung:	Toxoplasma gondii infects a wide range of hosts worldwide, including humans and domesticated animals causing toxoplasmosis disease. Recently, exosomes, small extracellular vesicles (EV) that contain nucleic acids, proteins, and lipids derived from their original cells were linked with disease protection. The effect of EVs derived from T. gondii on the immune response and its relevance in a physiological context is unknown. Here we disclose the first proteomic profiling of T. gondii EVs compared to EVs isolated from a human foreskin fibroblast infected cell line cultured in a vesicle‐free medium. Our results reveal a broad range of canonical exosomes proteins. Data are available via ProteomeXchange with the identifier PXD004895.
ISSN:	1615-9853 1615-9861
DOI:	10.1002/pmic.201600477