FE and experimental study on how the cortex material properties of synthetic femurs affect strain levels

Highlights • The RMS errors of predicted strains showed that modeling cortical bone with isotropic material properties led to higher errors. • The strain level of the cancellous bone can be significantly affected by the material properties of the cortical bone. • These results suggest that, in comparison with FE models, the µFE models will tend to decrease the fraction of cancellous tissue that is under low-loaded and increase the SD values. • The local behavior of femur-implanted systems can only be realistically improved if the composite behavior of cortical bone is numerically accounted for.