Multifocal Motor Neuropathy Associated With Infliximab: A Case Report and a Literature Review
Multifocal motor neuropathy with conduction block (MMN-CB) is purely a motor neuropathy with progressive weakness that is characteristically caused by conduction blocks. Association with antiganglioside antibodies and a good response to immunomodulating therapies suggest an autoimmune etiology. In r...
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| Veröffentlicht in: | The Neurologist (Baltimore, Md.) Md.), 2017-07, Vol.22 (4), p.144-146 |
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| container_title | The Neurologist (Baltimore, Md.) |
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| creator | Bayrak, Ayse O Ulusoy, Hasan Bolat, Necdet Doğan, Baki Ozbenli, Taner |
| description | Multifocal motor neuropathy with conduction block (MMN-CB) is purely a motor neuropathy with progressive weakness that is characteristically caused by conduction blocks. Association with antiganglioside antibodies and a good response to immunomodulating therapies suggest an autoimmune etiology. In rare cases, MMN-CB has been reported as an adverse effect of infliximab, a tumor necrosis factor-α blocker. We present a case of MMN-CB due to infliximab in a 45-year-old man with psoriatic arthritis who was exposed to the drug for 2 years because of a delayed diagnosis. We emphasize the possibility of this adverse effect and the importance of detailed electrophysiological examinations, which is supported by a review of the literature. |
| doi_str_mv | 10.1097/NRL.0000000000000132 |
| format | Article |
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| ispartof | The Neurologist (Baltimore, Md.), 2017-07, Vol.22 (4), p.144-146 |
| issn | 1074-7931 2331-2637 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Antirheumatic Agents - adverse effects Arthritis, Psoriatic - drug therapy Humans Infliximab - adverse effects Male Middle Aged Polyneuropathies - chemically induced Polyneuropathies - diagnosis Polyneuropathies - physiopathology |
| title | Multifocal Motor Neuropathy Associated With Infliximab: A Case Report and a Literature Review |
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