Multifocal Motor Neuropathy Associated With Infliximab: A Case Report and a Literature Review

Multifocal motor neuropathy with conduction block (MMN-CB) is purely a motor neuropathy with progressive weakness that is characteristically caused by conduction blocks. Association with antiganglioside antibodies and a good response to immunomodulating therapies suggest an autoimmune etiology. In r...

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Veröffentlicht in:The Neurologist (Baltimore, Md.) Md.), 2017-07, Vol.22 (4), p.144-146
Hauptverfasser: Bayrak, Ayse O, Ulusoy, Hasan, Bolat, Necdet, Doğan, Baki, Ozbenli, Taner
Format: Artikel
Sprache:eng
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Zusammenfassung:Multifocal motor neuropathy with conduction block (MMN-CB) is purely a motor neuropathy with progressive weakness that is characteristically caused by conduction blocks. Association with antiganglioside antibodies and a good response to immunomodulating therapies suggest an autoimmune etiology. In rare cases, MMN-CB has been reported as an adverse effect of infliximab, a tumor necrosis factor-α blocker. We present a case of MMN-CB due to infliximab in a 45-year-old man with psoriatic arthritis who was exposed to the drug for 2 years because of a delayed diagnosis. We emphasize the possibility of this adverse effect and the importance of detailed electrophysiological examinations, which is supported by a review of the literature.
ISSN:1074-7931
2331-2637
DOI:10.1097/NRL.0000000000000132