Cardiorespiratory responses of air filtration: A randomized crossover intervention trial in seniors living in Beijing: Beijing Indoor Air Purifier StudY, BIAPSY

In this Beijing Indoor Air Purifier StudY (BIAPSY), we conducted a randomized crossover intervention trial in a panel of 35 non-smoking senior participants with free-living, with and without chronic obstructive pulmonary disease (COPD). Portable air filtration units were randomly allocated to active...

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Veröffentlicht in:The Science of the total environment 2017-12, Vol.603-604, p.541-549
Hauptverfasser: Shao, Danqing, Du, Yipeng, Liu, Shuo, Brunekreef, Bert, Meliefste, Kees, Zhao, Qian, Chen, Jie, Song, Xiaoming, Wang, Meng, Wang, Juan, Xu, Hongbing, Wu, Rongshan, Wang, Tong, Feng, Baihuan, Lung, Candice Shih-Chun, Wang, Xian, He, Bei, Huang, Wei
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Sprache:eng
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Zusammenfassung:In this Beijing Indoor Air Purifier StudY (BIAPSY), we conducted a randomized crossover intervention trial in a panel of 35 non-smoking senior participants with free-living, with and without chronic obstructive pulmonary disease (COPD). Portable air filtration units were randomly allocated to active-(filter in) for 2weeks and sham-mode (filter out) for 2weeks in the households. We examined the differences in indoor air pollutant concentrations in 20 study homes and a suite of cardio-respiratory biomarker levels in study participants between filtration modes, with and without adjustment for potential confounders. Following active filtration, we observed significant reductions from 60±45 to 24±15μg/m in ten-day averages of indoor PM and reductions from 3.87±1.65 to 1.81±1.19m .10 in ten-day averages of indoor BC, compared to sham-mode filtration. The major components of indoor PM , including water soluble organics, NO , SO , Zn , Pb and K , were also reduced significantly by 42% to 63%. However, following active filtration, we only observed significant reductions on systemic inflammation measured as of IL-8 at 58.59% (95% CI: -76.31, -27.64) in the total group of participants and 70.04% (95% CI: -83.05, -47.05) in the subset of COPD patients, with adjustments. We were not able to detect improvements on lung function, blood pressure, and heart rate variability, following short-term intervention of two-week active air filtration. In conclusion, our results showed that indoor air filtration produced clear improvement on indoor air quality, but no demonstrable changes in the cardio-respiratory outcomes of study interest observed in the seniors living with real-world air pollution exposures.
ISSN:1879-1026
DOI:10.1016/j.scitotenv.2017.06.095