APOBEC3B and IL-6 form a positive feedback loop in hepatocellular carcinoma cells

APOBEC3 protein families, a DNA cytidine deaminase, were up-regulated in multiple tumors. However, the relationship between Hepatocellular carcinoma(HCC) and APOBEC3B(A3B) remains unknown. It has been confirmed that interleukin-6(IL-6)has significant impacts on oncogenesis of HCC. Here, we reported...

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Veröffentlicht in:Science China. Life sciences 2017-06, Vol.60 (6), p.617-626
Hauptverfasser: Li, Shuran, Bao, Xueyang, Wang, Duowei, You, Linjun, Li, Xianjing, Yang, Hongbao, Bian, Jinsong, Wang, Yun, Yang, Yong
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Sprache:eng
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Zusammenfassung:APOBEC3 protein families, a DNA cytidine deaminase, were up-regulated in multiple tumors. However, the relationship between Hepatocellular carcinoma(HCC) and APOBEC3B(A3B) remains unknown. It has been confirmed that interleukin-6(IL-6)has significant impacts on oncogenesis of HCC. Here, we reported that the expression of IL-6 was substantially up-regulated by A3 B in HepG2 cells. A3 B induced IL-6 expression through relocating HuR to enhance the IL-6 mRNA stability. Further analysis indicated that IL-6 also increased the expression of A3 B through JAK1/STAT3 signaling pathway, which formed a positive feedback to maintain the continuous expression of A3 B and IL-6, and thereby promoted the prolonged non-resolving inflammation. Collectively, these findings suggest that A3 B is essential for oncogenesis of HCC, and is a potential target for preventive intervention.
ISSN:1674-7305
1869-1889
DOI:10.1007/s11427-016-9058-6