Effect of epilepsy in pregnancy on fetal growth restriction: a systematic review and meta-analysis

Purpose Epilepsy is one of the most common neurological diseases during pregnancy. However, the influence of epilepsy on fetal growth is not understood. Thus, this study conducted a meta-analysis to determine the influence of epilepsy during pregnancy on fetal growth restriction (FGR). Methods BIOSI...

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Veröffentlicht in:	Archives of gynecology and obstetrics 2017-09, Vol.296 (3), p.421-427
Hauptverfasser:	Chen, Daijuan, Hou, Lisha, Duan, Xia, Peng, Hongling, Peng, Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anticonvulsants - adverse effects Anticonvulsants - therapeutic use Endocrinology Epilepsy Epilepsy - complications Epilepsy - drug therapy Female Fetal Development Fetal Growth Retardation - epidemiology Gynecology Health risk assessment Human Genetics Humans Medicine Medicine & Public Health Meta-analysis Obstetrics/Perinatology/Midwifery Pregnancy Pregnancy Complications Prenatal development Review Systematic review Womens health
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Zusammenfassung:	Purpose Epilepsy is one of the most common neurological diseases during pregnancy. However, the influence of epilepsy on fetal growth is not understood. Thus, this study conducted a meta-analysis to determine the influence of epilepsy during pregnancy on fetal growth restriction (FGR). Methods BIOSIS, Medline, Embase, and PubMed databases were searched between January 2000 and January 2016. Without imposing language or regional restrictions, referenced articles were selected. Results Final analysis included 684 citations from 11 studies. Estimated risk of FGR was 1.28-fold higher in epileptic pregnant women than in non-epileptic women [95% confidence interval (95% CI) 1.09–1.50, p
ISSN:	0932-0067 1432-0711
DOI:	10.1007/s00404-017-4404-y