HLA-F: A New Kid Licensed for Peptide Presentation

HLA-F: A New Kid Licensed for Peptide Presentation

HLA-F, a non-classical MHC molecule, is not known to present peptides. Dulberger et al. (2017) show that HLA-F contains a distinct peptide-binding groove and can present a diverse array of peptides. LIR1, however, recognized HLA-F away from bound peptide, leaving open whether peptide-HLA-F-specific...

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Veröffentlicht in:Immunity (Cambridge, Mass.) Mass.), 2017-06, Vol.46 (6), p.972-974
Hauptverfasser: Sim, Malcolm J.W., Sun, Peter D.
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Antigen presentation
Binding
Crystal structure
Histocompatibility antigen HLA
Humans
Ligands
Major histocompatibility complex
Peptides
Peptides - chemistry
Polypeptides
Protein Binding
Receptors
T cell receptors
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Zusammenfassung:HLA-F, a non-classical MHC molecule, is not known to present peptides. Dulberger et al. (2017) show that HLA-F contains a distinct peptide-binding groove and can present a diverse array of peptides. LIR1, however, recognized HLA-F away from bound peptide, leaving open whether peptide-HLA-F-specific T and NK receptors exist. HLA-F, a non-classical MHC molecule, is not known to present peptides. Dulberger et al. (2017) show that HLA-F contains a distinct peptide-binding groove and can present a diverse array of peptides. LIR1, however, recognized HLA-F away from bound peptide, leaving open whether peptide-HLA-F-specific T and NK receptors exist.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2017.06.004