Tumor-Stroma Ratio is an independent predictor for overall survival and disease free survival in gastric cancer patients

Abstract Background Despite different prognostic factors have been already studied, patients undergoing potentially curative resection for gastric cancer, still have a poor outcome. There is therefore the need to identify novel prognostic factors. Recently, Tumor-Stroma Ratio (TSR) was proven to be...

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Veröffentlicht in:	The surgeon (Edinburgh) 2017-12, Vol.15 (6), p.329-335
Hauptverfasser:	Aurello, Paolo, Berardi, Giammauro, Giulitti, Diego, Palumbo, Antonio, Tierno, Simone Maria, Nigri, Giuseppe, D'Angelo, Francesco, Pilozzi, Emanuela, Ramacciato, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	Disease free survival Gastrectomy Gastric cancer Humans Lymphatic Metastasis Neoplasm Invasiveness Neoplasm Staging Overall survival Prognosis Stomach - pathology Stomach - surgery Stomach Neoplasms - mortality Stomach Neoplasms - pathology Stomach Neoplasms - surgery Surgery Survival Analysis Tumor Burden Tumor Stroma Ratio
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Zusammenfassung:	Abstract Background Despite different prognostic factors have been already studied, patients undergoing potentially curative resection for gastric cancer, still have a poor outcome. There is therefore the need to identify novel prognostic factors. Recently, Tumor-Stroma Ratio (TSR) was proven to be associated with prognosis in different types of cancers. Aim of this study was to evaluate the prognostic value of TSR in gastric cancer patients. Methods 106 patients underwent gastrectomy between January 2004 and December 2015. Demographics and histopathological characteristics were collected. We considered a 50% TSR cutoff value to divide patients in Stroma-Rich (≥50%) and Stroma-Poor (
ISSN:	1479-666X 2405-5840
DOI:	10.1016/j.surge.2017.05.007