In situ generation of less accessible Boc-imines from aldehydes: construction of a quaternary carbon by the Mannich reaction or unprecedented aldol reaction

In situ generation of less accessible N-Boc-protected imines from aldehydes and their application to the direct three-component Mannich reaction with β-dicarbonyls were realized. The catalyst-free aldol reaction of ynals with β-dicarbonyls was also developed.