Patrolling monocytes sense peripheral infection and induce cytokine-mediated neuronal dysfunction
A new study reveals that virus-associated activation of a subset of circulating monocytes results in the release of the proinflammatory cytokine tumor necrosis factor (TNF)-α, which induces increased turnover of synapses in the brain and learning deficits in mice.
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| Veröffentlicht in: | Nature medicine 2017-06, Vol.23 (6), p.659-661 |
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| container_title | Nature medicine |
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| creator | Priller, Josef Böttcher, Chotima |
| description | A new study reveals that virus-associated activation of a subset of circulating monocytes results in the release of the proinflammatory cytokine tumor necrosis factor (TNF)-α, which induces increased turnover of synapses in the brain and learning deficits in mice. |
| doi_str_mv | 10.1038/nm.4349 |
| format | Article |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature |
| subjects | 13 13/21 14 14/69 631/378/1595 64 64/60 692/420/254 Allergens Allergies Asthma Bacterial infections Biomedicine Cancer Research Care and treatment CX3C Chemokine Receptor 1 Cytokines Dendritic Spines Dosage and administration Drug therapy Health aspects Immune system Infections Infectious Diseases Inflammation Interleukin-1 Metabolic Diseases Molecular Medicine Monocytes Neurons Neurosciences Neutrophils news-and-views Tumor necrosis factor Tumor Necrosis Factor-alpha Tumor necrosis factor-TNF Viral infections West Nile virus |
| title | Patrolling monocytes sense peripheral infection and induce cytokine-mediated neuronal dysfunction |
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