Patrolling monocytes sense peripheral infection and induce cytokine-mediated neuronal dysfunction

A new study reveals that virus-associated activation of a subset of circulating monocytes results in the release of the proinflammatory cytokine tumor necrosis factor (TNF)-α, which induces increased turnover of synapses in the brain and learning deficits in mice.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature medicine 2017-06, Vol.23 (6), p.659-661
Hauptverfasser:	Priller, Josef, Böttcher, Chotima
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/21 14 14/69 631/378/1595 64 64/60 692/420/254 Allergens Allergies Asthma Bacterial infections Biomedicine Cancer Research Care and treatment CX3C Chemokine Receptor 1 Cytokines Dendritic Spines Dosage and administration Drug therapy Health aspects Immune system Infections Infectious Diseases Inflammation Interleukin-1 Metabolic Diseases Molecular Medicine Monocytes Neurons Neurosciences Neutrophils news-and-views Tumor necrosis factor Tumor Necrosis Factor-alpha Tumor necrosis factor-TNF Viral infections West Nile virus
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Beschreibung
Zusammenfassung:	A new study reveals that virus-associated activation of a subset of circulating monocytes results in the release of the proinflammatory cytokine tumor necrosis factor (TNF)-α, which induces increased turnover of synapses in the brain and learning deficits in mice.
ISSN:	1078-8956 1546-170X
DOI:	10.1038/nm.4349