The role of prophylactic antiepileptic drugs for seizure prophylaxis in meningioma surgery: A systematic review

Highlights • Seizure rates amongst AED and no-AED seizure-naïve cohorts were similarly low. • Convexity location and oedema are associated with post-operative seizures. • The benefit of prophylactic AEDs could not be inferred in this systematic review. • Prospective randomised controlled trials are...

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Veröffentlicht in:	Journal of clinical neuroscience 2017-09, Vol.43, p.47-53
Hauptverfasser:	Islim, Abdurrahman I, McKeever, Stephen, Kusu-Orkar, Ter-Er, Jenkinson, Michael D
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticonvulsants - therapeutic use Antiepileptic drugs Craniotomy Craniotomy - adverse effects Craniotomy - methods Humans Meningeal Neoplasms - surgery Meningioma Meningioma - surgery Neurology Post-operative seizure Postoperative Complications - drug therapy Postoperative Complications - prevention & control Prophylaxis Seizures - drug therapy Seizures - prevention & control
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Beschreibung
Zusammenfassung:	Highlights • Seizure rates amongst AED and no-AED seizure-naïve cohorts were similarly low. • Convexity location and oedema are associated with post-operative seizures. • The benefit of prophylactic AEDs could not be inferred in this systematic review. • Prospective randomised controlled trials are needed to inform clinical practice.
ISSN:	0967-5868 1532-2653
DOI:	10.1016/j.jocn.2017.05.020