LINE-1 hypomethylation is associated to specific clinico-pathological features in Stage I non-small cell lung cancer
Highlights • The vast majority of stage I NSCLCs harbour at least one driver gene alteration. • Druggable mutations are present in stage I NSCLC. • LINE-1 hypomethylation is a striking feature of SqCC and correlates with smoking. • Stage IB, LINE-1 hypomethylation, and PIK3CA mutations could predict...
Gespeichert in:
| Veröffentlicht in: | Lung cancer (Amsterdam, Netherlands) Netherlands), 2017-06, Vol.108, p.83-89 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 89 |
|---|---|
| container_issue | |
| container_start_page | 83 |
| container_title | Lung cancer (Amsterdam, Netherlands) |
| container_volume | 108 |
| creator | Imperatori, Andrea Sahnane, Nora Rotolo, Nicola Franzi, Francesca Nardecchia, Elisa Libera, Laura Romualdi, Chiara Cattoni, Maria Sessa, Fausto Dominioni, Lorenzo Furlan, Daniela |
| description | Highlights • The vast majority of stage I NSCLCs harbour at least one driver gene alteration. • Druggable mutations are present in stage I NSCLC. • LINE-1 hypomethylation is a striking feature of SqCC and correlates with smoking. • Stage IB, LINE-1 hypomethylation, and PIK3CA mutations could predict patient prognosis |
| doi_str_mv | 10.1016/j.lungcan.2017.03.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1911199711</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S016950021730257X</els_id><sourcerecordid>1911199711</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-f26a1e4f6266874b8ec4e150c61782e73f4f434e3baab4c693e933f6456b67d73</originalsourceid><addsrcrecordid>eNqFkUtv1DAURi0EokPhJ4C8ZJPgV-xkA0JVgZFGZdEisbMc52bGQxIH20Gaf19HM7Bg0429Ofd1PoTeUlJSQuWHYzks096aqWSEqpLwkhD-DG1orVhRc86eo03mmqIihF2hVzEeSQYpaV6iK1ZLVslKbFDabe9uC4oPp9mPkA6nwSTnJ-wiNjF660yCDieP4wzW9c5iO7jJWV_MJh384PfOmgH3YNISIGI34ftk9oC3ePJTEUczDNhCftZ1cd7XQniNXvRmiPDm8l-jH19uH26-FbvvX7c3n3eFFYykomfSUBC9ZFLWSrQ1WAG0IlZSVTNQvBe94AJ4a0wrrGw4NJz3UlSylapT_Bq9P_edg_-9QEx6dHFdxkzgl6hpQyltGkVpRqszaoOPMUCv5-BGE06aEr0K10d9Ea5X4ZpwnYXnuneXEUs7Qvev6q_hDHw6A5AP_eMg6GgdZAudC2CT7rx7csTH_zqcIzDDLzhBPPolTNmipjoyTfT9mvoaOlWcsEr95I_QLamw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1911199711</pqid></control><display><type>article</type><title>LINE-1 hypomethylation is associated to specific clinico-pathological features in Stage I non-small cell lung cancer</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Imperatori, Andrea ; Sahnane, Nora ; Rotolo, Nicola ; Franzi, Francesca ; Nardecchia, Elisa ; Libera, Laura ; Romualdi, Chiara ; Cattoni, Maria ; Sessa, Fausto ; Dominioni, Lorenzo ; Furlan, Daniela</creator><creatorcontrib>Imperatori, Andrea ; Sahnane, Nora ; Rotolo, Nicola ; Franzi, Francesca ; Nardecchia, Elisa ; Libera, Laura ; Romualdi, Chiara ; Cattoni, Maria ; Sessa, Fausto ; Dominioni, Lorenzo ; Furlan, Daniela</creatorcontrib><description>Highlights • The vast majority of stage I NSCLCs harbour at least one driver gene alteration. • Druggable mutations are present in stage I NSCLC. • LINE-1 hypomethylation is a striking feature of SqCC and correlates with smoking. • Stage IB, LINE-1 hypomethylation, and PIK3CA mutations could predict patient prognosis</description><identifier>ISSN: 0169-5002</identifier><identifier>EISSN: 1872-8332</identifier><identifier>DOI: 10.1016/j.lungcan.2017.03.003</identifier><identifier>PMID: 28625654</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Aged ; Aged, 80 and over ; Biomarkers, Tumor ; Carcinoma, Non-Small-Cell Lung - diagnosis ; Carcinoma, Non-Small-Cell Lung - genetics ; Carcinoma, Non-Small-Cell Lung - mortality ; Carcinoma, Non-Small-Cell Lung - therapy ; DNA Methylation ; DNA Mutational Analysis ; Early stage ; Epigenesis, Genetic ; Female ; Follow-Up Studies ; Gene mutation ; Genetic Association Studies ; Hematology, Oncology and Palliative Medicine ; Humans ; LINE-1 hypomethylation ; Long Interspersed Nucleotide Elements ; Lung cancer ; Lung Neoplasms - diagnosis ; Lung Neoplasms - genetics ; Lung Neoplasms - mortality ; Lung Neoplasms - therapy ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Prognosis ; Prognostic factors ; Pulmonary/Respiratory ; Smoking ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Surgery ; Survival Analysis</subject><ispartof>Lung cancer (Amsterdam, Netherlands), 2017-06, Vol.108, p.83-89</ispartof><rights>Elsevier B.V.</rights><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-f26a1e4f6266874b8ec4e150c61782e73f4f434e3baab4c693e933f6456b67d73</citedby><cites>FETCH-LOGICAL-c420t-f26a1e4f6266874b8ec4e150c61782e73f4f434e3baab4c693e933f6456b67d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lungcan.2017.03.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28625654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Imperatori, Andrea</creatorcontrib><creatorcontrib>Sahnane, Nora</creatorcontrib><creatorcontrib>Rotolo, Nicola</creatorcontrib><creatorcontrib>Franzi, Francesca</creatorcontrib><creatorcontrib>Nardecchia, Elisa</creatorcontrib><creatorcontrib>Libera, Laura</creatorcontrib><creatorcontrib>Romualdi, Chiara</creatorcontrib><creatorcontrib>Cattoni, Maria</creatorcontrib><creatorcontrib>Sessa, Fausto</creatorcontrib><creatorcontrib>Dominioni, Lorenzo</creatorcontrib><creatorcontrib>Furlan, Daniela</creatorcontrib><title>LINE-1 hypomethylation is associated to specific clinico-pathological features in Stage I non-small cell lung cancer</title><title>Lung cancer (Amsterdam, Netherlands)</title><addtitle>Lung Cancer</addtitle><description>Highlights • The vast majority of stage I NSCLCs harbour at least one driver gene alteration. • Druggable mutations are present in stage I NSCLC. • LINE-1 hypomethylation is a striking feature of SqCC and correlates with smoking. • Stage IB, LINE-1 hypomethylation, and PIK3CA mutations could predict patient prognosis</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor</subject><subject>Carcinoma, Non-Small-Cell Lung - diagnosis</subject><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Carcinoma, Non-Small-Cell Lung - mortality</subject><subject>Carcinoma, Non-Small-Cell Lung - therapy</subject><subject>DNA Methylation</subject><subject>DNA Mutational Analysis</subject><subject>Early stage</subject><subject>Epigenesis, Genetic</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gene mutation</subject><subject>Genetic Association Studies</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>LINE-1 hypomethylation</subject><subject>Long Interspersed Nucleotide Elements</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Staging</subject><subject>Prognosis</subject><subject>Prognostic factors</subject><subject>Pulmonary/Respiratory</subject><subject>Smoking</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</subject><subject>Surgery</subject><subject>Survival Analysis</subject><issn>0169-5002</issn><issn>1872-8332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAURi0EokPhJ4C8ZJPgV-xkA0JVgZFGZdEisbMc52bGQxIH20Gaf19HM7Bg0429Ofd1PoTeUlJSQuWHYzks096aqWSEqpLwkhD-DG1orVhRc86eo03mmqIihF2hVzEeSQYpaV6iK1ZLVslKbFDabe9uC4oPp9mPkA6nwSTnJ-wiNjF660yCDieP4wzW9c5iO7jJWV_MJh384PfOmgH3YNISIGI34ftk9oC3ePJTEUczDNhCftZ1cd7XQniNXvRmiPDm8l-jH19uH26-FbvvX7c3n3eFFYykomfSUBC9ZFLWSrQ1WAG0IlZSVTNQvBe94AJ4a0wrrGw4NJz3UlSylapT_Bq9P_edg_-9QEx6dHFdxkzgl6hpQyltGkVpRqszaoOPMUCv5-BGE06aEr0K10d9Ea5X4ZpwnYXnuneXEUs7Qvev6q_hDHw6A5AP_eMg6GgdZAudC2CT7rx7csTH_zqcIzDDLzhBPPolTNmipjoyTfT9mvoaOlWcsEr95I_QLamw</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Imperatori, Andrea</creator><creator>Sahnane, Nora</creator><creator>Rotolo, Nicola</creator><creator>Franzi, Francesca</creator><creator>Nardecchia, Elisa</creator><creator>Libera, Laura</creator><creator>Romualdi, Chiara</creator><creator>Cattoni, Maria</creator><creator>Sessa, Fausto</creator><creator>Dominioni, Lorenzo</creator><creator>Furlan, Daniela</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170601</creationdate><title>LINE-1 hypomethylation is associated to specific clinico-pathological features in Stage I non-small cell lung cancer</title><author>Imperatori, Andrea ; Sahnane, Nora ; Rotolo, Nicola ; Franzi, Francesca ; Nardecchia, Elisa ; Libera, Laura ; Romualdi, Chiara ; Cattoni, Maria ; Sessa, Fausto ; Dominioni, Lorenzo ; Furlan, Daniela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-f26a1e4f6266874b8ec4e150c61782e73f4f434e3baab4c693e933f6456b67d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor</topic><topic>Carcinoma, Non-Small-Cell Lung - diagnosis</topic><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Carcinoma, Non-Small-Cell Lung - mortality</topic><topic>Carcinoma, Non-Small-Cell Lung - therapy</topic><topic>DNA Methylation</topic><topic>DNA Mutational Analysis</topic><topic>Early stage</topic><topic>Epigenesis, Genetic</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gene mutation</topic><topic>Genetic Association Studies</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>LINE-1 hypomethylation</topic><topic>Long Interspersed Nucleotide Elements</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Staging</topic><topic>Prognosis</topic><topic>Prognostic factors</topic><topic>Pulmonary/Respiratory</topic><topic>Smoking</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</topic><topic>Surgery</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Imperatori, Andrea</creatorcontrib><creatorcontrib>Sahnane, Nora</creatorcontrib><creatorcontrib>Rotolo, Nicola</creatorcontrib><creatorcontrib>Franzi, Francesca</creatorcontrib><creatorcontrib>Nardecchia, Elisa</creatorcontrib><creatorcontrib>Libera, Laura</creatorcontrib><creatorcontrib>Romualdi, Chiara</creatorcontrib><creatorcontrib>Cattoni, Maria</creatorcontrib><creatorcontrib>Sessa, Fausto</creatorcontrib><creatorcontrib>Dominioni, Lorenzo</creatorcontrib><creatorcontrib>Furlan, Daniela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Imperatori, Andrea</au><au>Sahnane, Nora</au><au>Rotolo, Nicola</au><au>Franzi, Francesca</au><au>Nardecchia, Elisa</au><au>Libera, Laura</au><au>Romualdi, Chiara</au><au>Cattoni, Maria</au><au>Sessa, Fausto</au><au>Dominioni, Lorenzo</au><au>Furlan, Daniela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LINE-1 hypomethylation is associated to specific clinico-pathological features in Stage I non-small cell lung cancer</atitle><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle><addtitle>Lung Cancer</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>108</volume><spage>83</spage><epage>89</epage><pages>83-89</pages><issn>0169-5002</issn><eissn>1872-8332</eissn><abstract>Highlights • The vast majority of stage I NSCLCs harbour at least one driver gene alteration. • Druggable mutations are present in stage I NSCLC. • LINE-1 hypomethylation is a striking feature of SqCC and correlates with smoking. • Stage IB, LINE-1 hypomethylation, and PIK3CA mutations could predict patient prognosis</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>28625654</pmid><doi>10.1016/j.lungcan.2017.03.003</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0169-5002 |
| ispartof | Lung cancer (Amsterdam, Netherlands), 2017-06, Vol.108, p.83-89 |
| issn | 0169-5002 1872-8332 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1911199711 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aged Aged, 80 and over Biomarkers, Tumor Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - therapy DNA Methylation DNA Mutational Analysis Early stage Epigenesis, Genetic Female Follow-Up Studies Gene mutation Genetic Association Studies Hematology, Oncology and Palliative Medicine Humans LINE-1 hypomethylation Long Interspersed Nucleotide Elements Lung cancer Lung Neoplasms - diagnosis Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - therapy Male Middle Aged Neoplasm Grading Neoplasm Staging Prognosis Prognostic factors Pulmonary/Respiratory Smoking Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Surgery Survival Analysis |
| title | LINE-1 hypomethylation is associated to specific clinico-pathological features in Stage I non-small cell lung cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T16%3A14%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=LINE-1%20hypomethylation%20is%20associated%20to%20specific%20clinico-pathological%20features%20in%20Stage%20I%20non-small%20cell%20lung%20cancer&rft.jtitle=Lung%20cancer%20(Amsterdam,%20Netherlands)&rft.au=Imperatori,%20Andrea&rft.date=2017-06-01&rft.volume=108&rft.spage=83&rft.epage=89&rft.pages=83-89&rft.issn=0169-5002&rft.eissn=1872-8332&rft_id=info:doi/10.1016/j.lungcan.2017.03.003&rft_dat=%3Cproquest_cross%3E1911199711%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1911199711&rft_id=info:pmid/28625654&rft_els_id=1_s2_0_S016950021730257X&rfr_iscdi=true |