LINE-1 hypomethylation is associated to specific clinico-pathological features in Stage I non-small cell lung cancer

Highlights • The vast majority of stage I NSCLCs harbour at least one driver gene alteration. • Druggable mutations are present in stage I NSCLC. • LINE-1 hypomethylation is a striking feature of SqCC and correlates with smoking. • Stage IB, LINE-1 hypomethylation, and PIK3CA mutations could predict...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2017-06, Vol.108, p.83-89
Hauptverfasser:	Imperatori, Andrea, Sahnane, Nora, Rotolo, Nicola, Franzi, Francesca, Nardecchia, Elisa, Libera, Laura, Romualdi, Chiara, Cattoni, Maria, Sessa, Fausto, Dominioni, Lorenzo, Furlan, Daniela
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biomarkers, Tumor Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - therapy DNA Methylation DNA Mutational Analysis Early stage Epigenesis, Genetic Female Follow-Up Studies Gene mutation Genetic Association Studies Hematology, Oncology and Palliative Medicine Humans LINE-1 hypomethylation Long Interspersed Nucleotide Elements Lung cancer Lung Neoplasms - diagnosis Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - therapy Male Middle Aged Neoplasm Grading Neoplasm Staging Prognosis Prognostic factors Pulmonary/Respiratory Smoking Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Surgery Survival Analysis
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Zusammenfassung:	Highlights • The vast majority of stage I NSCLCs harbour at least one driver gene alteration. • Druggable mutations are present in stage I NSCLC. • LINE-1 hypomethylation is a striking feature of SqCC and correlates with smoking. • Stage IB, LINE-1 hypomethylation, and PIK3CA mutations could predict patient prognosis
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2017.03.003